61306-81-8

Upstream product

• 4160-61-6 3-methoxycarbonyltetrahydropyran-4-one 

Downstream Products

• 108054-19-9 2-(4-Methoxy-phenyl)-4-oxo-4H-thiopyran-3-carboxylic acid methyl ester 
• 108054-23-5 2-(4-Methoxy-phenyl)-4-oxo-4H-thiopyran-3-carboxylic acid 
• 108054-20-2 2-(4-Methoxy-phenyl)-thiopyran-4-one 
• 78965-33-0 3,4-dihydro-2-phenyl-2H-thiopyran-4-one 
• 117169-61-6 2-allyl-3-butyl-3-cyclopenten-1-one ethylene acetal 
• 108054-08-6 2-(4-Methoxy-phenyl)-4-oxo-3,4-dihydro-2H-thiopyran-3-carboxylic acid methyl ester 
• 108054-07-5 4-Oxo-2-phenyl-3,4-dihydro-2H-thiopyran-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

The Preparation of Thiathromboxane Analogues and a Formal Total Synthesis of Dithiathroboxane A2 Based on Conjugate Addition Reactions of Thiin-4-ones

The conjugate addition of thiin-4-one and 3-methoxycarbonylthiin-4-one have been investigated.In contrast to thiin-4-one its 3-methoxycarbonyl derivative undergoes conjugate addition with range of organocopper reagents, the most efficient being copper-cat

THE SYNTHESIS OF THIATHROMBOXANE ANALOGUES

Thiathromboxane analogues (2) and (19) have been prepared by an extremely short and efficient synthetic route which can also be employed to make simple 2,3-dialkylated thian-4-ones.The cornerstone of the synthetic strategy is the organocopper conjugate addition - enolate alkylation reactions of 3-methoxycarbonyl-5,6-dihydrothiin-4-one (1b).