61319-45-7Relevant academic research and scientific papers
27. Carotinoid-Glycosylester. Synthese von 8'-Apo-β-carotin-8'-saure-(β-D-glucosyl)ester und Vitamin-A-saure-(β-D-glucosyl)ester
Pfander, Hanspeter,Laderach, Manfred,Wittwer, Fritz
, p. 277 - 283 (1980)
β-D-glucosyl 8'-apo-β-carotene-8'-oate (III) and β-D-glucosyl vitamin-A-oate (VI) were regio- and stereoselctively synthesized in high yields from the N-acyl-imidazoles I and IV, respectively, or from the N-acyltriazoles II and V, resprctively, and unprotected β-D-glucose, according to the method described for the synthesis of di(β-D-glucosyl) 8,8'-diapo-carotene8,8'-dioate .It seems that this method can generally be applied for the synthesis of β-D-glucosyl esters of polyene carboxylic acids.
Carotenoids with two chromophores: Carotenoid retinoates
Hertzberg, Sissel,Lutnaes, Bjart Frode,Liaaen-Jensen, Synnove
experimental part, p. 511 - 525 (2011/05/12)
In this study, carotenoid retinoates are described for the first time. The preparation was achieved by the azolide method. Various sec carotenols reacted with N-retinoylimidazol in the presence of catalytic amounts of sodium hydride. Mono- and diretinoates of (3R,3′R)-zeaxanthin and its (3S,3′S)- enantiomer, (9Z,9′Z; 3R,3′R)-alloxanthin, (3R,3′R)-7,8, 7′,8′-tetrahydro-3,3′-dihydroxy-β,β-carotene-8, 8′-dione and (3R,6R,3′R,6′R)-ε,ε-carotene-3, 3′-diol (lactucaxanthin), as well as monoretinoates of (3R,3′RS,6′R)-3′-methoxy-β,ε-caroten-3-ol, (3R,3′RS,6′R)-3-methoxy-β,ε-caroten-3′-ol, (2R,6′RS)-β,ε-caroten-2-ol, (3R,3′S; meso)-astaxanthin and (2′R)-aleuriaxanthin are reported in this study. Spectroscopic properties (1H-NMR mass spectrometry, visible and circular dichroism spectra) are discussed. Studies on other carotenoid derivatives with two chromophores are referred to here.
Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice
Patel, Jyoti B.,Huynh, Carlic K.,Handratta, Venkatesh D.,Gediya, Lalji K.,Brodie, Angela M. H.,Goloubeva, Olga G.,Clement, Omoshile O.,Nanne, Ivo P.,Soprano, Dianne Robert,Njar, Vincent C. O.
, p. 6716 - 6729 (2007/10/03)
Novel retinoic acid metabolism blocking agents (RAMBAs) have been synthesized and characterized. The synthetic features include introduction of nucleophilic ligands at C-4 of all-trans-retinoic acid (ATRA) and 13-cis-retinoic acid, and modification of ter
