61320-82-9Relevant academic research and scientific papers
7-[2-(2-Imino-4-thiazolin-4-yl)-2-(syn)-hydroxy-iminoacetamido]-cephalosporins
-
, (2008/06/13)
Disclosed are 2-(syn)-hydroxyimino-acetamide derivatives of the formula: STR1 wherein Y is hydrogen, hydroxyl, an acyloxy, carbamoyloxy, a quaternary ammonium or a nitrogen-containing heterocyclic ring-substituted thio group; or pharmaceutically acceptable salts or esters thereof are useful as antibacterial agents. Also disclosed are processes for producing them.
Cephalosporin displacement reaction
-
, (2008/06/13)
The present invention is directed to a process for the displacement of the acetoxy group of a cephalosporanic acid by a sulfur nucleophile, in an organic solvent and under essentially anhydrous conditions.
Cephalosporin derivatives
-
, (2008/06/13)
A series of novel 7-(Dα-aminophenylacetamido)- and 7-(D-α-hydroxyphenylacetamido)- Δ3 -cephem derivatives have been prepared wherein a heterocyclic thiomethyl moiety is located at the 3-position of the molecule. These compounds are useful as antibacterial agents for the treatment of diseases caused by Gram-positive and Gram-negative bacteria. Preferred members include 7-(D-α-hydroxyphenylacetamido)-3-(3-carbamoyl-1,2,4-triazol-5-yl)thiomethylceph-3-em-4-carboxylic acid and 7-(D-α-hydroxyphenylacetamido)-3-(2-carboxymethoxy-methyl-1,3,4-thiadiazol-5-yl)thiomethylceph-3-em-4-carboxylic acid. Alternative methods of preparation are provided for these compounds, including various synthetic routes leading to the required novel heterocyclic thiol intermediates.
