613230-03-8Relevant academic research and scientific papers
Pd-Catalyzed debenzylation and deallylation of ethers and esters with sodium hydride
Mao, Yujian,Liu, Ye,Hu, Yanwei,Wang, Liang,Zhang, Shilei,Wang, Wei
, p. 3016 - 3020 (2018/04/14)
Herein we demonstrate simply that the addition of Pd(OAc)2 as a promotor switches the reactivity of a commonly used base NaH to a nucleophilic reductant. The reactivity is engineered into a palladium-catalyzed reductive debenzylation and deallylation of aryl ethers and esters. This operationally simple, mild protocol displays a broad substrate scope and a broad spectrum of functional group tolerance (>50 examples) and high chemoselectivity toward aryl ethers over aliphatic structures. Moreover, the dual reactivity of NaH as a base and a reductant is demonstrated in efficient synthetic elaboration.
Application of metallide/palladium compound catalytic reduction system in debenzylation reaction and deuterization reaction
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Paragraph 0047, (2018/09/08)
The invention discloses an application of a metallide/palladium compound catalytic reduction system in debenzylation reaction and deuterization reaction of benzyl-containing compounds. The reaction comprises the following steps: under the protection of nitrogen, suspending a palladium compound and a metallide in a solvent, stirring for 5 minutes, adding the benzyl-containing compounds, carrying out a reaction for 0.5 to 48 h at the temperature of -30 DEG C to 150 DEG C, adding ice water to stop the reaction, adjusting the pH value to 3.5 with diluted hydrochloric acid, extracting the reactionsolution by a solvent, drying by distillation, purifying by column chromatography, and thus completing the reaction.
Synthesis of 1,6-ansaglycosides
Schulz, Tobias,Eicher, Theophil
, p. 1253 - 1261 (2007/10/03)
Two representatives of the 1,6-ansaglycoside class of compounds have been synthesized by different ring-closing strategies.
