613240-18-9

Basic information

• Product Name: 5-(4-TRIFLUOROMETHYLPHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 5-(4-TRIFLUOROMETHYLPHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID ETHYL ESTER;5-[4-(TRIFLUOROMETHYL)PHENYL]-3-ISOXAZOLECARBOXYLIC ACID ETHYL ESTER;ETHYL 5-[4-(TRIFLUOROMETHYL)PHENYL]ISOXAZOLE-3-CARBOXYLATE
• CAS NO: 613240-18-9
• Molecular Formula: C₁₃H₁₀F₃NO₃
• Molecular Weight: 285.22
• Mol File: 613240-18-9.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-(4-TRIFLUOROMETHYLPHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-TRIFLUOROMETHYLPHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID ETHYL ESTER(613240-18-9)
• EPA Substance Registry System: 5-(4-TRIFLUOROMETHYLPHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID ETHYL ESTER(613240-18-9)

Safety Data

• Hazardous Substances Data: 613240-18-9(Hazardous Substances Data)

Upstream product

• 705-31-7 4-trifluoromethylphenylacetylene 
• 623-33-6 glycine ethyl ester hydrochloride 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 1221821-79-9 ethyl 3-hydroxy-5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-3-isoxazolecarboxylate 
• 1221821-74-4 ethyl 5-hydroxy-5-[4-(trifluoromethyl)phenyl]-4,5-dihydro-3-isoxazolecarboxylate 
• 1221821-67-5 ethyl 2-hydroxy-4-oxo-4-[4-(trifluoromethyl)phenyl]-2-butenoate 
• 95-92-1 oxalic acid diethyl ester 
• 737790-81-7 ethyl 5-(4-(trifluoromethyl)phenyl)-4,5-dihydroisoxazole-3-carboxylate 
• 84-58-2 2,3-dicyano-5,6-dichloro-p-benzoquinone 
• 613240-19-0 2,4-dioxo-4-(4-trifluoromethylphenyl)butyric acid ethyl ester 
• 64-17-5 ethanol 
• 2922-61-4 lithium hydroxypyruvate 
• 1383527-52-3 4-hydroxy-2-oxo-4-(4-trifluoromethyl-phenyl)-but-3-enoic acid methyl ester 
• 14337-43-0 ethyl 2-chloro-2-(hydroxyimino)acetate 

Downstream Products

• 1314024-00-4 N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-5-(4-(trifluoromethyl)phenyl)-isoxazole-3-carboxamide 
• 1314023-94-3 5-(4-(trifluoromethyl)phenyl)-N-(3-phenylpropyl)isoxazole-3-carboxamide 
• 668970-85-2 5-(4-trifluoromethyl-phenyl)-isoxazole-3-carboxylic acid 
• 1273029-88-1 C₁₁H₄ClF₄NO₂ 
• 1110771-79-3 4-chloro-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carbonyl chloride 
• 1110771-83-9 4-fluoro-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylic acid 
• 1110771-77-1 4-chloro-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylic acid 
• 1110770-25-6 4-bromo-N-cyclopentyl-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide 
• 1110771-68-0 ethyl 4-bromo-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate 
• 613240-20-3 {5-[4-(trifluoromethyl)phenyl]isoxazol-3-yl}methan-1-ol 
• 1021879-78-6 methanesulfonic acid 5-(4-trifluoromethyl-phenyl)-isoxazol-3-ylmethyl ester 
• 1110771-76-0 ethyl-4-chloro-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate 
• 1110771-82-8 ethyl 4-fluoro-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate 

Relevant articles and documents

Oxidize Amines to Nitrile Oxides: One Type of Amine Oxidation and Its Application to Directly Construct Isoxazoles and Isoxazolines

A facile oxidative heterocyclization of commercially available amines and tert-butyl nitrite with alkynes or alkenes leading to isoxazoles or isoxazolines is described. The unprecedented strategy of the oxidation of an amine directly to a nitrile oxide was used in this cyclization process. This reaction is highly efficient, regiospecific, operationally simple, mild, and tolerant of a variety of functional groups. Control experiments support a nitrile oxide intermediate mechanism for this novel class of oxidative cyclization reactions. Moreover, synthetic applications toward bioactive molecular skeletons and the late-stage modification of drugs were realized.

Synthesis and cellular bioactivities of novel isoxazole derivatives incorporating an arylpiperazine moiety as anticancer agents

In our endeavour towards the development of effective anticancer therapeutics, a novel series of isoxazole-piperazine hybrids were synthesized and evaluated for their cytotoxic activities against human liver (Huh7 and Mahlavu) and breast (MCF-7) cancer ce

Structure-activity studies of a novel series of isoxazole-3-carboxamide derivatives as TRPV1 antagonists

Optimisation of a screening hit incorporating both TRPV1 activity and solubility was conducted. Substitution of the isoxazole-3-carboxamide with the bespoke 1S, 3R-3-aminocyclohexanol motif afforded the requisite balance of potency and solubility. Compounds 32 and 40 were found to have antihyperalgesic effects in the rat CFA Hg assay and induce a mechanism based hyperthermia.