61325-71-1

Usage

Uses

Used in Pharmaceutical Industry:
2-ethyl-4-(4-Methyl-1-piperazinyl)10H-Thieno[2,3-b][1,5]benzodiazepine is used as a potential therapeutic agent for the treatment of anxiety disorders due to its benzodiazepine core and the presence of a methyl-piperazinyl group, which may contribute to its anxiolytic properties.
Used in Sleep Aid Formulations:
In the pharmaceutical industry, 2-ethyl-4-(4-Methyl-1-piperazinyl)10H-Thieno[2,3-b][1,5]benzodiazepine may be utilized as an ingredient in sleep aid formulations, given its potential sedative effects, which could help alleviate insomnia and other sleep-related issues.
Used in Muscle Relaxant Formulations:
2-ethyl-4-(4-Methyl-1-piperazinyl)10H-Thieno[2,3-b][1,5]benzodiazepine may also be used in muscle relaxant formulations, potentially providing relief from muscle spasms and tension, due to its structural similarity to other benzodiazepines known for their muscle-relaxing properties.

Upstream product

• 1493-27-2 ortho-nitrofluorobenzene 
• 635302-32-8 2‐amino‐5‐ethylthiophene‐3‐carbonitrile 
• 109-01-3 1-methyl-piperazine 
• 61325-38-0 2-ethyl-5,10-dihydro-benzo[b]thieno[2,3-e][1,4]diazepin-4-one 

Relevant academic research and scientific papers

COMPOUND FOR THE TREATMENT OF CNS DISORDERS

The present invention relates to the compound 2-ethyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine and its use as is or in substantially pure form in the treatment of CNS disorders including schizophrenia and bipolar disorder. The compound is prepared by reacting a substituted thiophene compound with 2-fluoronitrobenzene to form, after ring closure and reaction with N-methylpiperazine, the title compound. The compound is then purified to substantially pure form and is useful as an antipsychotic. The compound may also be combined with other active ingredients including HMG CoA reductase inhibitors such as lovastatin or simvastatin and/or antidepressants such as fluxoetine or other SSRIs to form medically useful combination products useful in treating psychotic conditions and depression while also preventing any rise beyond the normal range of cholesterol levels in any subset of patients that might develop such a condition.

4-Piperazinyl-10H-thienobenzodiazepines as Potential Neuroleptics

A series of 4-substituted 10H-thienobenzodiazepines has been synthesized.These compounds have been assessed for their ability to block a conditioned avoidance response (CAR) and to produce catalepsy in rats and have been compared with several