613262-16-1 Usage
Uses
Used in Pharmaceutical Research and Drug Development:
5-bromobenzo[d]isothiazol-3-amine is used as a chemical compound in pharmaceutical research and drug development for its potential applications in creating new medications.
Used in Antifungal Applications:
5-bromobenzo[d]isothiazol-3-amine is used as an antifungal agent due to the antimicrobial activity of the isothiazole ring, which is known for its effectiveness against fungal infections.
Used in Antibacterial Applications:
5-bromobenzo[d]isothiazol-3-amine is used as an antibacterial agent, leveraging the antimicrobial properties of the isothiazole ring to combat bacterial infections.
Used in Antiviral Applications:
5-bromobenzo[d]isothiazol-3-amine is used as an antiviral agent, potentially inhibiting viral replication and infection due to its unique molecular structure and functional groups.
Used in Various Industries:
5-bromobenzo[d]isothiazol-3-amine may find applications across different industries where its biological properties can be harnessed for specific purposes, such as in agriculture for crop protection or in material science for the development of new compounds with antimicrobial properties.
Check Digit Verification of cas no
The CAS Registry Mumber 613262-16-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,1,3,2,6 and 2 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 613262-16:
(8*6)+(7*1)+(6*3)+(5*2)+(4*6)+(3*2)+(2*1)+(1*6)=121
121 % 10 = 1
So 613262-16-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H5BrN2S/c8-4-1-2-6-5(3-4)7(9)10-11-6/h1-3H,(H2,9,10)
613262-16-1Relevant academic research and scientific papers
Discovery of dual death-associated protein related apoptosis inducing protein kinase 1 and 2 inhibitors by a scaffold hopping approach
Gao, Ling-Jie,Kovackova, Sona,?ála, Michal,Ramadori, Anna Teresa,De Jonghe, Steven,Herdewijn, Piet
, p. 7624 - 7643 (2015/01/08)
DRAK2 emerged as a promising drug target for the treatment of autoimmune diseases and to prevent graft rejection after organ transplantation. Screening of a compound library in a DRAK2 binding assay led to the identification of an isothiazolo[5,4-b]pyridine derivative as a novel ligand for DRAK2, displaying a Kdvalue of 1.6 μM. Subsequent medicinal chemistry work led to the discovery of a thieno[2,3-b]pyridine derivative with strong DRAK2 binding affinity (Kd= 9 nM). Moreover, this compound also behaves as a functional inhibitor of DRAK2 enzymatic activity, displaying an IC50value of 0.82 μM, although lacking selectivity, when tested against DRAK1. This paper describes for the first time functionally active dual DRAK1 and DRAK2 inhibitors that can be used as starting point for the synthesis of chemical tool compounds to study DRAK1 and DRAK2 biology, or they can be considered as hit compounds for hit-to-lead optimization campaigns in drug discovery programs.
