61327-65-9Relevant academic research and scientific papers
Gram-Scale, Cheap, and Eco-Friendly Iron-Catalyzed Cross-Coupling between Alkyl Grignard Reagents and Alkenyl or Aryl Halides
Cahiez, Gérard,Lefèvre, Guillaume,Moyeux, Alban,Guerret, Olivier,Gayon, Eric,Guillonneau, Lo?c,Lefèvre, Nicolas,Gu, Qinzhuo,Zhou, Edouard
, p. 2679 - 2683 (2019/04/30)
A new robust methodology for gram-scale iron-catalyzed cross-coupling between alkyl Grignard reagents and alkenyl or aryl halides is developed. This method does not require toxic additives such as NMP or expensive ligands. Its efficiency relies on the use of simple alkoxide magnesium salts as additives. On the basis of these results, a new procedure for one-pot synthesis of substituted benzamides from chloroesters is also proposed.
Process for the preparation of a 2-alkylpyrimidine
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, (2008/06/13)
The process according to the invention for the preparation of a 2-propyl- or 2-butylpyrimidine, in which the corresponding 2-alkyl-1,4,5,6-tetrahydropyrimidine is dehydrogenated in the gas phase with a palladium-containing catalyst and in which a 2-propyl- or 2-butylpyrimidine is recovered from the reaction mixture, is characterized in that the gas-phase reaction is carried out using a carbon monoxide-hydrogen reactant. As this is understood a mixture of carbon monoxide and hydrogen and/or a compound capable of at least partial decomposing into CO and H2 under the reaction conditions.
