61335-18-0Relevant academic research and scientific papers
A facile synthesis, spectral (IR, 1H, 13C & 31P NMR) characteristics and antimicrobial activity of 6-aryloxy/arylthio/alkylamino dibenzo [d,f][1,3,2]-dioxaphosphepin 6-sulfides
Kumar, K. Ananda,Kasthuraiah,Reddy, C. Suresh,Nagaraju
, p. 313 - 318 (2003)
A series of 6-aryloxy/arylthio/alkylamino dibenzo[d,f][1,3,2]-dioxaphosphepin 6-sulfides (4) were synthesized with a two step process with moderate yields starting from 2,2N-dihydroxybiphenyl (1) and thiophosphoryl chloride (2). Initially, the intermediat
Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: A structure-activity study
Mott, Bryan T.,He, Ran,Chen, Xiaochun,Fox, Jennifer M.,Civin, Curt I.,Arav-Boger, Ravit,Posner, Gary H.
, p. 3702 - 3707 (2013/07/27)
We recently reported the anti-cancer and anti-cytomegalovirus (CMV) activity of artemisinin-derived trioxane diphenylphosphate dimer 838. To probe the relationship between chemical structure and anti-CMV and anti-cancer activities, we now report synthesis and evaluation of a series of eight new dimer phosphate ester analogs of 838. This series of novel molecules was screened against human foreskin fibroblasts (HFFs) infected with CMV and against the human Jurkat T cell acute lymphoblastic leukemia cell line. This SAR study confirms the very high anti-CMV and anti-cancer potencies of dimer diphenyl phosphate ester 838 without its being toxic to normal cells.
DIBENZO(d,f)-1,3,2-DIOXAPHOSPHOREPINE UND METALLKOMPLEXE VON 2,2'-BIPHENYLYLENPHOSPHORSAEREN
Kuchen, W.,Mahler, H. F.
, p. 139 - 146 (2007/10/02)
Synthesis and properties of dibenzo(d,f)-1,3,2-dioxaphosphorepines of general formula X: O,S Y: viz.OH, SH, Cl R = 2.2'-biphenylylen are reported.The compounds with Y = OH or SH, which may be also named 2.2'-biphenylylenposphoric acids, form metal complexes in which, depending on the type of donor atom (S and /or O), the acid anion acts as a chelating or bridging ligand.
