61337-86-8Relevant articles and documents
Iridium-catalyzed silylation of aryl C-H bonds
Cheng, Chen,Hartwig, John F.
, p. 592 - 595 (2015/01/30)
A method for the iridium-catalyzed silylation of aryl C-H bonds is described. The reaction of HSiMe(OSiMe3)2 with arenes and heteroarenes catalyzed by the combination of [Ir(cod)(OMe)]2 and 2,4,7-trimethylphenanthroline occurs with the aromatic compound as the limiting reagent and with high levels of sterically derived regioselectivity. This new catalytic system occurs with a much higher tolerance for functional groups than the previously reported rhodium-catalyzed silylation of aryl C-H bonds and occurs with a wide range of heteroarenes. The silylarene products are suitable for further transformations, such as oxidation, halogenation, and cross-coupling. Late-stage functionalization of complex pharmaceutical compounds was demonstrated.
The synthesis of glucuronides derived from the antidepressant drugs mianserin and Org 3770
Van Boeckel,Delbressine,Kaspersen
, p. 259 - 265 (2007/10/02)
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