61349-71-1Relevant academic research and scientific papers
Highly selective palladium-catalyzed cross-coupling of secondary alkylzinc reagents with heteroaryl halides
Yang, Yang,Niedermann, Katrin,Han, Chong,Buchwald, Stephen L.
, p. 4638 - 4641 (2015/01/08)
The highly selective palladium-catalyzed Negishi coupling of secondary alkylzinc reagents with heteroaryl halides is described. The development of a series of biarylphosphine ligands has led to the identification of an improved catalyst for the coupling of electron-deficient heterocyclic substrates. Preparation and characterization of oxidative addition complex (L)(Ar)PdBr provided insight into the unique reactivity of catalysts based on CPhos-type ligands in facilitating challenging reductive elimination processes.
