613669-18-4

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(naphthalen-1-yloxy)-benzoic acid is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the creation of a wide range of drug molecules, contributing to the development of new treatments and therapies.
Used in Dye Production:
In the chemical industry, 2-(naphthalen-1-yloxy)-benzoic acid is utilized as a precursor in the production of dyes. Its chemical properties enable the creation of a variety of colorants used in different applications, such as textiles, plastics, and printing inks.
Used in Organic Compounds Synthesis:
2-(naphthalen-1-yloxy)-benzoic acid is used as a versatile building block in the synthesis of other organic compounds. Its reactivity and structural features make it a valuable component in the creation of complex molecules for various applications.
Used in Heterocyclic Compounds Production:
2-(naphthalen-1-yloxy)-benzoic acid has shown potential as an intermediate in the production of heterocyclic compounds with biological activity. Its role in the synthesis of these compounds is significant for the development of new bioactive molecules with potential applications in medicine and other fields.

Upstream product

• 90-15-3 α-naphthol 
• 16463-38-0 potassium 2-chlorobenzoate 
• 1135619-98-5 2-(naphthalen-1-yloxy)-benzoic acid ethyl ester 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 394-47-8 2-fluorobenzonitrile 
• 88-67-5 2-Iodobenzoic acid 

Downstream Products

• 239-30-5 benzo[b]naphtho[2,1-d]furan 
• 3402-76-4 1-phenoxynaphthalene 
• 550-97-0 benzophenyl salicylate 
• 613670-98-7 [2-(naphthalene-1-yloxy)-phenyl]acetic acid 
• 613670-92-1 [2-(naphthalene-1-yloxy)-phenyl]-acetonitrile 
• 82657-75-8 1-(2-bromomethyl-phenoxy)-naphthalene 
• 613670-83-0 [2-(naphthalene-1-yloxy)-phenyl]-methanol 

Relevant academic research and scientific papers

Formal Aniline Synthesis from Phenols through Deoxygenative N-Centered Radical Substitution

Phenolic, lignin-derived substrates have emerged as desirable biorenewable chemical feedstocks for coupling reactions. A radical-mediated conversion of phenol derivatives to anilines is reported, using unfunctionalized hydroxamic acids as the N-centered radical source. The applicability of this triethyl phosphite mediated O-atom transfer approach, which tolerates a range of steric and electronic demands to naturally occurring phenols and lignin models, has been demonstrated in this work to access the corresponding aniline derivatives.

A photoredox-neutral Smiles rearrangement of 2-aryloxybenzoic acids

We report on the use of visible light photoredox catalysis for the radical Smiles rearrangement of 2-aryloxybenzoic acids to obtain aryl salicylates. The method is free of noble metals and operationally simple and the reaction can be run under mild batch or flow conditions. Being a redox neutral process, no stoichiometric oxidants or reductants are needed.

Carboxyl radical-assisted 1,5-aryl migration through Smiles rearrangement

We report herein, a silver(i)-catalyzed Smiles rearrangement of 2-aryloxy- or 2-(arylthio)benzoic acids to provide aryl-2-hydroxybenzoate or aryl-2-mercaptobenzoate dimer, respectively, through 1,5-aryl migration from oxygen or sulfur to carboxylate oxygen. Mechanistically, the aryl ether moiety undergoes an intramolecular ipso attack by the carboxyl radical followed by a C-O or C-S bond cleavage. Aryl-2-mercaptobenzoates undergo oxidative dimerization through a thiol moiety in situ.

Synthesis of naphtho[2,3-b]-and naphtho[1,2-b]-fused thieno[2,3-d][1] benzoxepins and thieno[2,3-d][1]-benzothiepins

Synthesis of four novel classes of structurally related fused hetero-pentacyclic compounds, naphtho[2,3-b]thieno[2,3-d][1]benzothiepins (Ia), naphtho[1,2-b]thieno[2,3-d][1]benzothiepins (IIa), naphtho[2,3-b]thieno-[2,3-d] [1]benzoxepins (Ib, c) and naphth

1- OR 3-THIA-BENZONAPHTHOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF

The present invention relates to 1- or 3-thiabenzonaphthoazulene derivatives to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to t