61367-30-4

Usage

Uses

Used in Anticancer Applications:
1-(2-Chloroethyl)-3-(4α-methoxycyclohexan-1α-yl)-1-nitrosourea is used as a chemotherapy drug for the treatment of various types of cancer, including brain tumors, melanoma, and Hodgkin's lymphoma. It is effective due to its alkylating action on DNA, which interferes with the replication and transcription processes, leading to the destruction of cancer cells.
Used in Pharmaceutical Industry:
1-(2-Chloroethyl)-3-(4α-methoxycyclohexan-1α-yl)-1-nitrosourea is used as an active pharmaceutical ingredient for the development of cancer treatment drugs. Its potential anticancer properties make it a valuable compound in the creation of new medications aimed at combating various forms of cancer.

InChI:InChI=1/C10H18ClN3O3/c1-17-9-4-2-8(3-5-9)12-10(15)14(13-16)7-6-11/h8-9H,2-7H2,1H3,(H,12,15)

Upstream product

• 61367-29-1 1-(2-Chloro-ethyl)-3-(4-methoxy-cyclohexyl)-urea 
• 61367-42-8 4-Methoxycyclohexanon-oxim 
• 130290-78-7 (cis)-4-methoxycyclohexanamine hydrochloride 

Relevant academic research and scientific papers

Synthesis of analogues of N (2 chloroethyl) N' trans 4 methylcyclohexyl) N nitrosourea for evaluation as anticancer agents

The superior activity of N (2 chloroethyl) N' (trans 4 methylcyclohexyl) N nitrosourea (MeCCNU) against advanced murine Lewis lung carcinoma in comparisons with the cis form and other nitrosoureas prompted the synthesis of a number of MeCCNU analogues, including several cis trans pairs. The methyl group was replaced by a variety of substituents (CO2H, CH2CO2H, CO2Me, CH2OAc, CH2Cl, OMe); the trans 3 methylcyclohexyl, cis 2 methyl 1,3 dithian 5 yl, cis and trans 2 methyl 1,3 dithian 5 yl tetraoxide, and 1 methylhexyl (open chain) analogues were also prepared. Preliminary tests against murine leukemia L1210 revealed therapeutic indices (ED50/LD10) ranging from 0.26 to 0.79; all but 3 analogues effected 50% cure rates at nontoxic doses, the open chain analogue being one of the least active. In terms of therapeutic index, diequatorial (trans 4) isomers were, with one exception, as active as or, in 4 of the 8 examples, somewhat more active than the corresponding axial equatorial (cis 4) isomers. In this series, 4 of the 5 2-fluoroethyl analogues prepared were clearly inferior to the corresponding 2 chloroethyl analogues.