61367-67-7Relevant academic research and scientific papers
Lipophilicity and serotonin agonist activity in a series of 4 substituted mescaline analogues
Nichols,Dyer
, p. 299 - 301 (2007/10/06)
Replacement of the 4 methoxy of mescaline with higher alkyl homologues or with bromine led to increased activity at serotonin receptors in a sheep umbilical artery preparation. This activity appears correlated with lipophilicity, as measured by 1 octanol water partition coefficients, but drops off when the 4 substituent is about five atoms in length. It is suggested that 3,4,5 trisubstitution may give compounds which are as active as those with the 2,4 5 substitution pattern.
