613686-52-5Relevant academic research and scientific papers
Formation of quaternary chiral centers by N-Heterocyclic carbene-CuCatalyzed asymmetric conjugate addition reactions with grignard reagents on trisubstituted cyclic enones
Kehrli, Stefan,Martin, David,Rix, Diane,Mauduit, Marc,Alexakis, Alexandre
, p. 9890 - 9904 (2010)
The copper-catalyzed conjugate addition of Grignard reagents to 3-substituted cyclic enones allows the formation of all-carbon chiral quaternary centers. We demonstrate in this article that N-heterocyclic carbenes act as efficient chiral ligands for this transformation. High enantioselectivities (up to 96% ee) could be obtained for a variety of substrates.
