613686-83-2

Upstream product

• 62851-29-0 1-(4-chloro-phenyl)-5-oxo-3-phenyl-pyrrolidine-2,2-dicarboxylic acid diethyl ester 
• 5203-01-0 diethyl 2-[(4-chlorophenyl)amino]malonate 
• 102-92-1 Cinnamoyl chloride 
• 1307780-27-3 diethyl 1-(4-chlorophenyl)-5-thioxo-3-phenyl-pyrrolidine-2,2-dicarboxylate 

Relevant academic research and scientific papers

NaBH4-I2 mediated chemoselective reduction of γ-lactam and thio-γ-lactam in presence of gem-dicarboxylates: An easy access to 1,3-diaryl pyrrolidines

Substituted pyrrolidine derivatives were synthesized in high yield by NaBH4/I2 mediated chemoselective reduction of N-aryl-γ-lactam and N-aryl-thio-γ-lactam-2,2-dicarboxylate. With excess NaBH4/I2, carbonyl func

Chemoselective reduction of a lactam carbonyl group in the presence of a gem-dicarboxylate by sodium borohydride and iodine: A facile entry to N-aryl trisubstituted pyrroles

Several N-aryl γ-lactam gem dicarboxylates were chemoselectively reduced to cyclic amine diesters by using sodium borohydride-iodine system. The reduction in all cases was completed within 2.5 h after refluxing in THF. The cyclic amine products were isolated after aqueous (acidic) workup in good yields. Hydrolytic decarboxylation followed by dehydrogenation produced N-aryl carboethoxy pyrroles.