61369-40-2

Usage

Potential properties

Antioxidant, anti-inflammatory

Derivative

Pteridines

Biological roles

Enzyme catalysis, signal transduction

Structural features

Phenyl group, tetrahydrobenzo ring

Biological activities

Possibly related to aromatic and cyclic nature

Isomers

3H and 7H

Tautomerism

Potential for different chemical reactivity and biological effects

Further research

Needed to understand pharmacological and toxicological properties

Upstream product

• 61369-38-8 (methyl-1-phenylcarbamoyl)imino-2-hexahydro-1,2,5,6,7,8-quinoxalinecarboxylate-3 de methyle 
• 103-71-9 phenyl isocyanate 
• 670-80-4 4-cyclohexen-1-ylmorpholine 
• 61369-36-6 3-amino-4-methyl-4,6,7,8-tetrahydro-quinoxaline-2-carboxylic acid methyl ester 
• 61369-38-8 4-methyl-3-(phenylcarbamoyl-imino)-3,4,5,6,7,8-hexahydro-quinoxaline-2-carboxylic acid methyl ester 

Downstream Products

• 61369-42-4 methyl-10-phenyl-3-iso-alloxazine 

Relevant academic research and scientific papers

Nouvelle voie d'acces aux iso-alloxazines par l'intermediaire d'alkyl-1-amino-2-tetrahydro-1,5,6,7-quinoxaline-3-carbonitriles (ou carboxylate de methyle)

A new synthetic approach to iso-alloxazines using 1-alkyl-2-amino-1,5,6,7-tetrahydroquinoxaline-3-carbonitriles (or the corresponding methylcarboxylates) is reported.These key intermediates, accessible in two steps from cyclohexanone-enamines, when treated alkyl(aryl)iso-cyanates, guanidine or alkylchloroformates yield tetrahydro-iso-alloxazine derivatives, which can be dehydrogenated.Thus 3,10-dialkyl, 10-alkyl-3-aryl, 10-alkyl-iso-alloxazines or their 2-imino-4-oxo, 4-imino-2-oxo and 2,4-bisimino derivatives were obtained.The regiospecific aspect of this approach is illustrated by the synthesis of naphto, naphto or dimethyl-7,8 benzo pteridine derivatives.Tautomeric behavior or the tetrahydro intermediates and some limitations of the method are discussed.