61371-44-6Relevant academic research and scientific papers
NTETRAHYDROPYRIDOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF CANCER
-
Page/Page column 73-74, (2008/06/13)
Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
TETRAHYDROBENZOTHIOPHENE DERIVATIVES
-
Page/Page column 187, (2008/06/13)
Compounds of a certain formula I, in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
Novel Tetrahydropyridothiophenes
-
Page/Page column 64, (2008/12/04)
Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
Facile syntheses of 4-hydroxy-7-methyl-1-indanone, isolated from cyanobacterium Nostoc commune
Kamat, Shrivallabh P.,Menezes, Jose C.,Siddhaye, Bhushan M.,Paknikar, Shashikumar K.
experimental part, p. 1597 - 1599 (2009/04/07)
Two different high yielding synthetic routes both starting with 6-methylcoumarin 2 have been described to prepare 4-hydroxy-7-methyl-1-indanone 1, a constituent of cyanobacterium Nostoc commune having antibacterial activity. In the first route, methylative lactone ring opening of the coumarin 2 followed by catalytic hydrogenation of the cinnamyl double bond and subsequent PPA cyclization gives the methyl ether 5 of 1 which on demethylation gives 1 in excellent yield. Alternatively, catalytic hydrogenation of 2 followed by fusion with anhydrous AlCl3 gives high yield of 1 in just two steps.
TETRAHYDROPYRIDOTHIOPHENES AS ANTRIPOLIFERATIVE AGENTS FOR THE TREATMENT OF CANCER
-
Page/Page column 114, (2008/06/13)
The invention relates to compounds of formula (I) wherein Ra is -C(O)ORI, in which R1 is 1-7C-a.kyl. 3-7C-cycoakyl, 1-7C-alkyl substituted by Raa, or 2-7C-alky substituted by Rab and Rac on different carbon atoms, Rb is -T-Q, in which T is 1-6C-alkylene or 3-7C-cycloalkylene, and Q is substituted by Rba and Rbb and Rbc, and is phenyl, wich are useful for the therapy of hyperprolif erative diseases, in particular human cancer.
