6138-79-0 Usage
Chemical Properties
TRIPROLIDINE HYDROCHLORIDE is a white, crystalline powder.
Uses
Different sources of media describe the Uses of 6138-79-0 differently. You can refer to the following data:
1. TRIPROLIDINE HYDROCHLORIDE is used as bulk pharmaceutical (antihistaminic). Product Data Sheet
2. trans-Triprolidine Hydrochloride is a potent H1 receptor antagonist. Anti-histamines.
Definition
TRIPROLIDINE HYDROCHLORIDE is a hydrate that is the monohydrate form of triprolidine hydrochloride. A sedating antihistamine, it is used for the symptomatic relief of uticaria, rhinitis, and various pruritic skin disorders.
General Description
Different sources of media describe the General Description of 6138-79-0 differently. You can refer to the following data:
1. Triprolidine hydrochloride,(E)-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine monohydrochloridemonohydrate (Actidil), is a white crystalline powder with a slight, but unpleasant, odor. It is soluble inwater and in alcohol, and its solutions are alkaline to litmus.The antihistaminic activity is confined mainly to the geometricisomer in which the pyrrolidinomethyl group is transto the 2-pyridyl group. Pharmacological studies confirm thehigh activity of triprolidine and the superiority of (E) overcorresponding (Z) isomers as H1-antihistamines. At guineapig ileum sites, the affinity of triprolidine for H-receptorswas more than 1,000 times the affinity of its (Z) diasteromer.The relative potency of triprolidine is of the same orderas that of dexchlorpheniramine. The peak effect occursabout 3.5 hours after oral administration, and the duration ofeffect is about 12 hours.
2. Odorless white crystalline powder. Bitter taste.
Air & Water Reactions
Water soluble.
Reactivity Profile
Triprolidine hydrochloride discolors on exposure to light.
Health Hazard
SYMPTOMS: Symptoms of exposure to Triprolidine hydrochloride may include depression to stimulation of the central nervous system, dry mouth, fixed dilated pupils, flushing, hallucinations, convulsions, urinary retention, cardiac arrhythmias and coma. Other symptoms may include excitability, drowsiness, nervousness, dizziness, high fever and sleeplessness. It can also cause sedation. It may also cause local anesthesia, dryness of the throat and nose and abdominal pain with vomiting or diarrhea.
Fire Hazard
Flash point data for Triprolidine hydrochloride are not available; however, Triprolidine hydrochloride is probably combustible.
Biological Activity
Potent H 1 receptor antagonist.
Check Digit Verification of cas no
The CAS Registry Mumber 6138-79-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,1,3 and 8 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 6138-79:
(6*6)+(5*1)+(4*3)+(3*8)+(2*7)+(1*9)=100
100 % 10 = 0
So 6138-79-0 is a valid CAS Registry Number.
InChI:InChI=1/C19H22N2.ClH.H2O/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;;/h2-3,6-12H,4-5,13-15H2,1H3;1H;1H2/b18-11+;;
