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Usage

Uses

Used in Pharmaceutical Synthesis:
Isatin-3-cyanohydrin is utilized as a key intermediate in the pharmaceutical industry for the preparation of various drugs. Its unique structure and reactivity allow for the development of new pharmaceutical compounds with potential therapeutic benefits.
Used in Agrochemical Production:
In the agrochemical sector, isatin-3-cyanohydrin serves as an important intermediate for the synthesis of agrochemicals. Its application contributes to the development of new products designed to protect crops and enhance agricultural productivity.
Used in Dye Manufacturing:
Isatin-3-cyanohydrin is also employed in the dye industry as a crucial intermediate for the production of various dyes. Its chemical properties enable the creation of dyes with specific characteristics, catering to different industrial needs.
Used in Biological Research:
Isatin-3-cyanohydrin has been studied for its potential biological activities, such as anticancer, antiviral, and antibacterial properties. This research is valuable for exploring new avenues in medicine and healthcare, potentially leading to the discovery of novel treatments and therapies.
Used in Organic Synthesis:
As a versatile building block, isatin-3-cyanohydrin is widely used in organic synthesis for the preparation of diverse chemical products. Its unique structural features and reactivity make it an essential component in the synthesis of complex organic molecules for various applications.

Upstream product

• 1092114-59-4 3-iodo-1H-indole-5-carbonitrile 
• 33348-34-4 4-amino-3-iodobenzonitrile 
• 15861-24-2 1H-indole-5-carbonitrile 
• 15861-23-1 indoline-5-carbonitrile 

Relevant academic research and scientific papers

Facile synthesis of isatins by direct oxidation of indoles and 3-iodoindoles using NIS/IBX

A facile one-pot access to a broad range of isatins by direct oxidation of indoles using NIS/IBX reagent in DMSO at 25 °C in very good isolated yields is reported. It is shown by mechanistic investigations that a number of substituted indoles react rapidly with NIS in DMSO to produce intermediary 3-iodoindoles, which undergo oxidation subsequently to isatins with IBX.

Method for preparing indole-2,3-dione derivatives by catalytic oxidation of microwave copper/peroxyacetic acid

The invention discloses a method for preparing indole-2,3-dione derivatives by catalytic oxidation of microwave copper/peroxyacetic acid. The method comprises the following steps: a catalytic amount of catalyst copper iodide, indole, a derivative of the indole and peroxyacetic acid are added into a reaction vessel, wherein the indole, the derivative of the indole and the peroxyacetic acid are usedas raw materials, ethanol is used as a solvent, the reaction vessel is placed into a microwave reaction instrument, a reaction is performed at certain temperature and power, after a certain time, reduced-pressure concentration is performed, and a product is purified by column chromatography. The method provided by the invention is a method having novel raw materials, simple operation and high efficiency used for preparing a benzimidazole derivative; and compared with the prior art, the method provided by the invention has an obviously-accelerated reaction speed than that under conventional heating, mild reaction conditions, simple operation, a high yield, safety, low costs and environmental protection.

An efficient method based on indoles for the synthesis of isatins by taking advantage of I2O5 as oxidant

An efficient method to synthesize isatins based on indoles by using inorganic hypervalent I2O5 has been explored in good yields, which successfully realized the transformation from indoles to isatins under metal-free, mild condition

A Palladium-Catalyzed Double Carbonylation Approach to Isatins from 2-Iodoanilines

A high-yielding procedure for the synthesis of isatins has been developed. Sequential Pd-catalyzed double carbonylation of 2-iodoanilines with near stoichiometric amounts of CO followed by acid-promoted cyclization readily affords an array of isatins. The conversion of 2-iodoanilines to isatins in good to excellent yields was found to proceed with good functional group tolerance. This protocol proved adaptable to 13C-isotope labeling of isatins, which was extended to the synthesis of the 13C-isotope labeled antiviral drug metisazone and the experimental anti-schizophrenia drug ML137.

Indium(III) chloride/2-iodoxybenzoic acid: A novel reagent system for the conversion of indoles into isatins

Indoles and azaindoles undergo smooth oxidation with 2-iodoxybenzoic acid (IBX) in the presence of indium(III) chloride at 80°C to afford the corresponding isatins in excellent yields. This method is very useful for the direct preparation of isatins from indoles. The reaction proceeds smoothly in aqueous media and the products are obtained in excellent yields. Georg Thieme Verlag Stuttgart.

Air oxidation of oxindoles to isatins

An aniline is converted to a 3-lower hydrocarbonthiooxindole by processes already known in the art and then air oxidized in an inert liquid vehicle in the presence of a base. The inert liquid vehicle advantageously is aprotic and the base is non-nucleophilic. Also, the aprotic liquid vehicle is desirably solvent for the starting 3-lower hydrocarbonthiooxindole and the non-nucleophilic base.