61396-73-4Relevant academic research and scientific papers
Lewis Base Catalyzed Dioxygenation of Olefins with Hypervalent Iodine Reagents
Pan, Liangkun,Ke, Zhihai,Yeung, Ying-Yeung
supporting information, p. 8174 - 8178 (2021/10/25)
1,2-Diols are extremely useful building blocks in organic synthesis. Hypervalent iodine reagents are useful for the vicinal dihydroxylation of olefins to give 1,2-diols under metal-free conditions, but strongly acidic promoters are often required. Herein, we report a catalytic vicinal dioxygenation of olefins with hypervalent iodine reagents using Lewis bases as catalysts. The conditions are mild and compatible with various functional groups.
INHIBITORS OF JANUS KINASES
-
Page/Page column 44, (2010/01/12)
The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3, TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
INHIBITORS OF JANUS KINASES
-
Page/Page column 78, (2009/01/23)
The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
1-(2-Ar-4-R-1,3-dioxolan-2-ylmethyl)imidazoles
-
, (2008/06/13)
1-(2-Ar-4-R-1,3-dioxolan-2-ylmethyl)imidazoles, useful as antifungal and antibacterial agents.
