6142-15-0

Usage

Uses

Used in Scientific Research:
2-Amino-4-methylthiazole hydrochloride is used as a chemical intermediate for the synthesis of various complex chemical compounds. Its unique structure allows for a broad range of potential chemical reactions, making it a valuable component in the development of new substances and materials.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Amino-4-methylthiazole hydrochloride is used as a building block for the creation of new drug molecules. Its versatility in chemical reactions enables the design of novel therapeutic agents with potential applications in treating various diseases and medical conditions.
Used in Chemical Synthesis:
2-Amino-4-methylthiazole hydrochloride is used as a reagent in the synthesis of other specialized chemical compounds. Its presence in the hydrochloride form and the presence of an amino group provide a foundation for further chemical modifications and the creation of new molecules with specific properties and functions.

InChI:InChI=1/C4H6N2S.ClH/c1-3-2-7-4(5)6-3;/h2H,1H3,(H2,5,6);1H

Upstream product

• 294886-88-7 2-(4-oxothiazolidine-2-iminyl)thiazol-4-acetic acid ethyl ester 

Downstream Products

• 89179-76-0 (4-methyl-thiazol-2-yl)-urea 
• 71119-13-6 N-(4-{[(4-methyl-2-thiazolyl)amino]sulfonyl}phenyl)-acetamide 
• 133692-16-7 5-bromo-4-methyl-thiazol-2-ylamine; hydrochloride 
• 5316-76-7 5-chloro-4-methylthiazol-2-amine 

Relevant academic research and scientific papers

Synthesis and antimicrobial activity of 4-carbethoxymethyl-2-[(α- haloacyl)amino]thiazoles and 5-nonsubstituted/substituted 2-[(4- carbethoxymethylthiazol-2-yl)imino]-4-thiazolidinones

4-Carbethoxymethyl-2-[(chloroacetyl/α-chloropropionyl/α- bromobutyryl/α-chloro-(α-phenylacetyl)amino]thiazoles (I-IV) were synthesized by reacting 4-carbethoxymethyl-2-aminothiazole with chloroacetyl chloride, α-chloropropionyl chloride, α-bromobutyryl bromide and α-chloro- α-phenylacetyl chloride, respectively. Furthermore, I-IV were refluxed with ammonium thiocyanate to give 2-[(4-carbethoxymethylthiazol-2-yl)imino]-4- thiazolidinones (V-VIII). V was refluxed with various aromatic aldehydes to give 5-arylidene-2-[(4-carbethoxymethylthiazol-2-yl)imino]-4-thiazolidinones (IX-XIV). The structures of synthesized compounds were confirmed by elemental analyses, hydrolysis, UV, IR, 1H-NMR and EI mass spectral data. The antimicrobial activities of the compounds were assessed by microbroth dilution technique using Mueller-Hinton broth and Mueller-Hinton Agar. In this study, Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, Escherichia coli ATCC 8739, Klebsiella pneumoniae ATCC 4352, Pseudomonas aeruginosa ATCC 1539, Salmonella typhi, Shigella flexneri, Proteus mirabilis and Candida albicans ATCC 10231 were used as test microorganisms. Among the tested compounds, XI and XIV showed activity against S. aureus (MIC: 78 μg/ml, 1.6 μg/ml), whereas compound V had an activity against S. flexneri (MIC: 39 μg/ml) and compound I against C. albicans (MIC: 125 (μg/ml). Compounds I, IV-XIV were also evaluated for antituberculosis activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system and BACTEC 12B medium. Only compounds I and XIV showed 86% and 67% inhibition in the primary screen.