61436-80-4Relevant academic research and scientific papers
Allenylphosphine oxides as simple scaffolds for phosphinoylindoles and phosphinoylisocoumarins
Gangadhararao,Kotikalapudi, Ramesh,Reddy, M. Nagarjuna,Swamy Kumara
supporting information, p. 996 - 1005 (2014/05/20)
A range of phosphinoylindoles was prepared in one-pot from functionalized propargyl alcohols and a suitable P(III) precursor via a base-mediated reaction. The reaction proceeds via the intermediacy of allenylphosphine oxides. Similarly, phosphinoylisocoumarins were prepared from allenylphosphine oxides in a trifluoroacetic acid-mediated reaction; the latter also acts as a solvent. Interestingly, in the presence of wet trifluoroacetic acid, in addition to phosphinoylisocoumarins, phosphorus-free isocoumarins were also obtained. Key products were characterized by single crystal X-ray crystallography.
