61448-56-4Relevant academic research and scientific papers
One-pot access to a library of structurally diverse nicotinamide derivatives via a three-component formal Aza [3 + 3] cycloaddition
Tenti, Giammarco,Teresa Ramos,Carlos Menendez
, p. 551 - 557 (2013/02/22)
The three-component formal [3 + 3] aza-annulation between chalcones, β-ketoamides, and ammonium acetate in the presence of CAN as a Lewis acid affords good to excellent yields of highly substituted nicotinamides or their fused derivatives. This transformation leads to the formation of one C-C and two C-N bonds in a single synthetic operation and involves up to five individual steps.
Synthesis of 4,6-Disubstituted 2-Methylpyridines and their 3-Carboxamides
Shibata, Katsuyoshi,Katsuyama, Isamu,Izoe, Hideaki,Matsui, Masaki,Muramatsu, Hiroshige
, p. 277 - 281 (2007/10/02)
A new one-pot synthesis of title compounds by the reactions of α,β-unsaturated carbonyl compounds with β-aminocrotononitrile in the presence of sodium hydroxide is described.
