61449-63-6

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 214554-44-6 5-(4’-carboxyphenyl)dipyrromethane 
• 266341-19-9 1,9-bis(benzoyl)-5-(4-methylphenyl)dipyrromethane-diol 
• 109-97-7 pyrrole 
• 619-66-9 4-Carboxybenzaldehyde 
• 57105-80-3 5,10,15-tris(4-methylphenyl)-20-(4-methoxycarbonylphenyl)porphyrin 
• 147804-55-5 5-(4-methylphenyl)dipyrromethane 

Downstream Products

• 91879-46-8 zinc(II) 5-(4-carboxyphenyl)-10,15,20-tris(4-methylphenyl)porphyrin 
• 784151-82-2 Zn(II)-5-[4-(hydroxymethyl)phenyl]-10,15,20-tri-ptolylporphyrin 
• 121869-50-9 5-(4-hydroxymethylphenyl)-10,15,20-tris(4-methylphenyl)porphyrin 
• 61449-64-7 5,10,15-tri(p-tolyl)-20-(p-carboxyphenyl)porphyrin acid chloride 
• 76196-48-0 5-(p-benzoyloxypropyl 2,5-dimethoxyphenylacetate)-10,15,20-tri(p-tolyl)porphyrin 
• 76196-49-1 5-(p-benzoyloxypropyl 2-hydroxy-5-methoxyphenylacetate)-10,15,20-tri(p-tolyl)porphyrin 
• 61449-64-7 5-(p-benzoyl chloride)-10,15,20-tri(p-tolyl)porphyrin 
• 91289-49-5 N-(2,5-dimethoxyphenylacetyl)-N'-(5-p-benzoyl-10,15,20-tri-p-tolylporphyrin)-1,4-diaminobutane 
• 87586-70-7 N-(2,5-dimethoxyphenylacetyl)-N'-(5-p-benzoyl-10,15,20-tri-p-tolylporphyrin)-1,3-diaminopropane 

Relevant academic research and scientific papers

Synthesis and DNA photocleavage studies of novel porphyrin diarylthiazoles

A convenient and regioselective synthesis of porphyrin diarylthiazoles is reported via the reactions of alkynyl(aryl)iodonium tosylates and porphyrin thioamides. Among the synthesized porphyrin diarylthiazoles, compounds 6d and 6f have shown significant i

Synthesis of peptidyl phosphonates containing 5-(4′-carboxyphenyl)- 10,15,20-tritolylporphyrin

The synthesis and characterization of three new porphyrin-peptidyl- phosphonate derivatives, containing a diphenyl 3-pyridylmethylphosphonate moiety, is described. These compounds could serve as potential photosensitizers for the PDT method of tumor thera

Synthesis of new porphyrin-containing peptidyl phosphonates

Synthesis of new, porphyrin-containing peptidyl aminophosphonates is described. The products, derived from 5-(4′-carboxyphenyl)-10,15,20-tri-p- tolylporphyrin and some heterocyclic aminophosphonates were obtained in high yield in the reaction of the 5-(4′

Three-Dimensional Structure-Activity Analysis of a Series of Porphyrin Derivatives with Anti-HIV-1 Activity Targeted to the V3 Loop of the gp120 Envelope Glycoprotein of the Human Immunodeficiency Virus Type 1

Using comparative molecular field analysis (CoMFA), a 3D-QSAR model was developed for 21 porphyrin derivatives which have anti-HIV-1 activity and bind to the V3 loop of the envelope glycoprotein gp120 of the human immunodeficiency virus type 1.A significa

Light-induced energy transfer followed by electron transfer in axially co-ordinated benzothiazole tethered zinc porphyrin-fullero[C60/C70]pyrrolidine triads

Benzothiazole (BTZ)-zinc porphyrin (ZnP) dyads, Dyad-1 and Dyad-2 connected together with two different spacers, ester and ethoxy esters, were synthesized and light induced energy and electron transfer events were investigated. Within these dyads, due to

B,B-diporphyrinbenzyloxy-BODIPY dyes: Synthesis and antenna effect

B,B-Diporphyrinbenzyloxy-BODIPY derivatives have been prepared in high yields, and the photophysical properties are reported. Singlet energy transfers from BODIPY to the porphyrin units have been analyzed.

Electronic energy harvesting multi BODIPY-zinc porphyrin dyads accommodating fullerene as photosynthetic composite of antenna-reaction center

Efficient electronic energy transfer (EET) in the newly synthesized dyads comprised of zinc porphyrin covalently linked to one, two or four numbers of boron dipyrrin (BDP) entities is investigated. Both steady-state and time-resolved emission as well as t

An efficient route to VEGF-like peptide porphyrin conjugates via microwave-assisted 'click-chemistry'

Synthetic cyclopeptides, and particularly those derived from VEGF sequence, present considerable interest for the development of nanodevices devoted to tumour imaging or targeting. In order to provide selective peptide-targeted tetrapyrrolic structures, w

The spectroscopic characterisation of proline derivatives of tolyl-porphyrins and their iron and cobalt complexes

The new tolylporphyrin-prolin derivatives: TTP-CONH-Pro-COOCH2C6H5 and TTP-NHCO-Pro-Cbz and their iron and cobalt complexes have been synthesised and characterised by MS, IR, UV-vis, EPR and LIOAS spectroscopy studies. The EPR investigations demonstrate that Fe(III) and Co(II) ions are located in the site of distorted axial symmetry. Besides, for ferric porphyrins a thermally induced spin crossover was observed. The possibility of the applications in photodynamic therapy or diagnostics of cancerous tissues of the porphyrins obtained was studied. In the light of the experiments performed, from the group of investigated compounds, it seems that the metal-free TTP-NHCO-Pro-Cbz is well suited for PDT.

Compositions and methods for treating cancer

The invention features compositions and methods for treating or alleviating a symptom of cancer. The compositions and methods of the invention direct supra-lethal doses of radiation, called Hot-Spots, to virtually all cancer cell types.