614754-45-9Relevant academic research and scientific papers
Stereoselective synthesis of phosphoramidate α(2-6)sialyltransferase transition-state analogue inhibitors
Skropeta, Danielle,Schwoerer, Ralf,Schmidt, Richard R.
, p. 3351 - 3354 (2007/10/03)
The asymmetric synthesis of novel, potent phosphoramidate α(2-6)sialyltransferase transition-state analogue inhibitors such as (R) -9 (Ki=68 μM) is described, via condensation of cytidine phosphitamide 6 with key chiral, non-racemic α-aminophosphonates, prepared in >98% ee by Mitsunobu azidation followed by Staudinger reduction of the corresponding chiral, non-racemic α-hydroxyphosphonates.
