614761-24-9Relevant academic research and scientific papers
Novel heterocyclic glucocorticoids: In vitro profile and in vivo efficacy
Thompson, Christopher F.,Quraishi, Nazia,Ali, Amjad,Tata, James R.,Hammond, Milton L.,Balkovec, James M.,Einstein, Monica,Ge, Lan,Harris, Georgianna,Kelly, Theresa M.,Mazur, Paul,Pandit, Shilpa,Santoro, Joseph,Sitlani, Ayesha,Wang, Chuanlin,Williamson, Joanne,Miller, Douglas K.,Yamin, Ting-Ting D.,Thompson, Chris M.,O'Neill, Edward A.,Zaller, Dennis,Forrest, Michael J.,Carballo-Jane, Ester,Luell, Silvi
, p. 2163 - 2167 (2007/10/03)
A series of novel ligands for the glucocorticoid receptor containing two heterocycles were synthesized. These compounds were investigated for a dissociative profile using transrepression and transactivation assays. Several compounds were tested in vivo and showed the ability to reduce inflammation in a mouse.
