614761-27-2Relevant articles and documents
Novel N-Arylpyrazolo[3,2-c]-Based Ligands for the Glucocorticoid Receptor: Receptor Binding and in Vivo Activity
Ali, Amjad,Thompson, Christopher F.,Balkovec, James M.,Graham, Donald W.,Hammond, Milton L.,Quraishi, Nazia,Tata, James R.,Einstein, Monica,Ge, Lan,Harris, Georgianna,Kelly, Terri M.,Mazur, Paul,Pandit, Shilpa,Santoro, Joseph,Sitlani, Ayesha,Wang, Chuanlin,Williamson, Joanne,Miller, Douglas K.,Thompson, Chris M.,Zaller, Dennis M.,Forrest, Michael J.,Carballo-Jane, Ester,Luell, Silvi
, p. 2441 - 2452 (2004)
A novel series of selective ligands for the human glucocorticoid receptor (hGR) are described. Preliminary structure-activity relationships were focused on substitution at C-1 and indicated a preference for 3-, 4-, and 5-substituted aromatic and benzylic