614763-05-2Relevant academic research and scientific papers
Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: Synthesis, in vitro profile, molecular modeling studies, and in vivo experiments
Thompson, Christopher F.,Quraishi, Nazia,Ali, Amjad,Mosley, Ralph T.,Tata, James R.,Hammond, Milton L.,Balkovec, James M.,Einstein, Monica,Ge, Lan,Harris, Georgianna,Kelly, Terri M.,Mazur, Paul,Pandit, Shilpa,Santoro, Joseph,Sitlani, Ayesha,Wang, Chuanlin,Williamson, Joanne,Miller, Douglas K.,Yamin, Ting-ting D.,Thompson, Chris M.,O'Neill, Edward A.,Zaller, Dennis,Forrest, Michael J.,Carballo-Jane, Ester,Luell, Silvi
, p. 3354 - 3361 (2008/02/07)
Chemistry was developed to synthesize the title series of compounds. The ability of these novel ligands to bind to the glucocorticoid receptor was investigated. These compounds were also tested in a series of functional assays and some were found to displ
