61489-71-2

Basic information

• Product Name: HUMAN MENOPAUSAL GONADOTROPHIN
• Synonyms: MENOPAUSAL GONADOTROPHIN, HUMAN URINE;MENOTROPIN;HMG;HUMAN MENOPAUSAL GONADOTROPHIN;HUMAN MENOPAUSAL GONADOTROPIN;GONADOTROPIN;GONADOTROPIN, HUMAN MENOPAUSAL URINE;gonadotropin,humanmenopausal
• CAS NO: 61489-71-2
• Molecular Formula: C9H18O
• Molecular Weight: 142.23862
• Product Categories: Peptides
• Mol File: 61489-71-2.mol
• Article Data: 0

Chemical Properties

• Appearance: White or off-white powder
• Storage Temp.: 2-8°C
• CAS DataBase Reference: HUMAN MENOPAUSAL GONADOTROPHIN(CAS DataBase Reference)
• NIST Chemistry Reference: HUMAN MENOPAUSAL GONADOTROPHIN(61489-71-2)
• EPA Substance Registry System: HUMAN MENOPAUSAL GONADOTROPHIN(61489-71-2)

Safety Data

• Hazard Codes: B
• WGK Germany: 3
• RTECS: MT6425640
• Hazardous Substances Data: 61489-71-2(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 61489-71-2 differently. You can refer to the following data:
1. Gonad-stimulating principle.
2. Gonadotropin from human menopausal urine has been used as a supplement in pre-incubated maturation medium for the culture of bovine cumulus oocyte complexes (COCs) to study the effects of multiple freeze-thawing of bovine epididymal sperm on in vitro development of embryo.

Brand name

Humegon (Organon); Pergonal (Serono).

General Description

Pituitary hormones prepared from the urine of postmenopausalwomen whose ovarian tissue does not respondto gonadotropin are available for medicinal use as theproduct menotropins (Pergonal). The latter has FSH andLH gonadotropin activity in a 1:1 ratio. Menotropins areuseful in the treatment of anovular women whose ovariesrespond to pituitary gonadotropins but who have a gonadotropindeficiency caused by either pituitary or hypothalamusmalfunction. Usually, menotropins are administeredintramuscularly in an initial dose of 75 IU of FSHand 75 IU of LH daily for 9 to 12 days, followed by 10,000IU of chorionic gonadotropin 1 day after the last dose ofmenotropins.

Biochem/physiol Actions

Gonadotropin interacts with members of the GPCR (G-protein coupled receptor family), and upon activation they induce adenylyl cyclase. This hormone is synthesized in male reproductive tract and has high concentration in semen, especially the a subunit. This subunit is linked with spermatogenesis, and lower levels are present in males with aberrant semen quality.

Clinical Use

Menotropins are a natural product that is obtained from the urine of postmenopausal women and then biologically standardized (international units [IU]) for FSH and LH activities in an approximate ratio of 1:1. Menotropins are used in males with primary (hypothalamic) or secondary (pituitary) hypogonadism to stimulate spermatogenesis, providing they have been treated previously with human chorionic gonadotropin (hCG; a peptide hormone of placental origin that has activity very similar to LH) to effect masculinization (increased testosterone inducing ovulation in women who are having difficulty ovulating as a result of either hypothalamic or pituitary hormonal dysfunction. The menotropins are given for 7 to 12 days, and after clinical evaluation (via ultrasound) indicates the presence of a mature follicle, a single dose of hCG is given to simulate the typical LH surge that normally triggers ovulation. Also, women use the combination of menotropins and hCG to promote the development of multiple follicles when they are participating in an IVF program requiring the recruitment of follicles.