61507-88-8

Basic information

• Product Name: 5-AMINO-1-PROPYL-1H-IMIDAZOLE-4-CARBOXAMIDE
• Synonyms: 5-AMINO-1-PROPYL-1H-IMIDAZOLE-4-CARBOXAMIDE;5-amino-1-propyl-1H-imidazole-4-carboxamide(SALTDATA: FREE)
• CAS NO: 61507-88-8
• Molecular Formula: C₇H₁₂N₄O
• Molecular Weight: 168.2
• Mol File: 61507-88-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 424.865°C at 760 mmHg
• Flash Point: 210.751°C
• Appearance: /
• Density: 1.377g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: 5-AMINO-1-PROPYL-1H-IMIDAZOLE-4-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-1-PROPYL-1H-IMIDAZOLE-4-CARBOXAMIDE(61507-88-8)
• EPA Substance Registry System: 5-AMINO-1-PROPYL-1H-IMIDAZOLE-4-CARBOXAMIDE(61507-88-8)

Safety Data

• Hazardous Substances Data: 61507-88-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H12N4O/c1-2-3-11-4-10-5(6(11)8)7(9)12/h4H,2-3,8H2,1H3,(H2,9,12)

Upstream product

• 107-10-8 propylamine 
• 6719-21-7 2-Amino-2-cyanoacetamide 
• 149-73-5 trimethyl orthoformate 
• 37842-62-9 ethyl N-(carbamoylcyanomethyl)formamidate 
• 122-51-0 orthoformic acid triethyl ester 
• 72-40-2 5-amino-1H-imidazole-4-carboxamide monohydrochloride 
• 106-94-5 propyl bromide 

Downstream Products

• 155581-73-0 5-(2-ethoxybenzamido)-1-n-propylimidazole-4-carboxamide 
• 22917-85-7 9-propylguanine 
• 155581-70-7 2-(2-ethoxyphenyl)-9-n-propylpurin-6-one 
• 131490-65-8 5-<amino>-1-propyl-1H-imidazole-4-carboxamide 

Relevant articles and documents

Studies on the π-π Stacking features of imidazole units present in a series of 5-amino-1-alkylimidazole-4-carboxamides

Reaction of 2-ethoxymethyleneamino-2-cyanoacetamide with primary alkyl amines in acetonitrile solvent affords 1-substituted-5-aminoimidazole-4-carboxamides. Single crystal X-ray diffraction studies of these imidazole compounds show that there are both anti-parallel and syn-parallel π-π stackings between two imidazole units in parallel-displaced (PD) conformations and the distance between two π-π stacked imidazole units depends mainly on the anti/ syn-parallel nature and to some extent on the alkyl group attached to N-1 of imidazole; molecules with anti-parallel PD-stacking arrangements of the imidazole units have got vertical π-π stacking distance short enough to impart stabilization whereas the imidazole unit having syn-parallel stacking arrangement have got much larger π-π stacking distances. DFT studies on a pair of anti-parallel imidazole units of such an AICA lead to curves for 'π-π stacking stabilization energy vs. π-π stacking distance' which have got similarity with the 'Morse potential energy diagram for a diatomic molecule' and this affords to find out a minimum π-π stacking distance corresponding to the maximum stacking stabilization energy between the pair of imidazole units. On the other hand, a DFT calculation based curve for 'π-π stacking stabilization energy vs. π-π stacking distance' of a pair of syn-parallel imidazole units is shown to have an exponential nature.

PURINONE ANTIANGINAL AGENTS

Compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein R1 is C1-C4 alkyl; R2 is C2-C4 alkyl; R3 is H or SO2NR4R5; R4 and R5 together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino, morpholino or 4-N-(Rs)-1-piperazinyl group; and R6 is H or C1-C3 alkyl; are selective cGMP PDE inhibitors useful in the treatment of, Inter alia, cardiovascular disorders such as angina, hypertension, heart failure and atherosclerosis.