615252-69-2Relevant academic research and scientific papers
Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides
Mai, Antonello,Massa, Silvio,Pezzi, Riccardo,Simeoni, Silvia,Rotili, Dante,Nebbioso, Angela,Scognamiglio, Annamaria,Altucci, Lucia,Loidl, Peter,Brosch, Gerald
, p. 3344 - 3353 (2007/10/03)
Chemical manipulations performed on aroyl-pyrrolyl-hydroxyamides (APHAs) led to (aryloxopropenyl)pyrrolyl hydroxamates 2a-w, and their inhibition against maize HDACs and their class I or class II HDAC selectivity were determined. In particular, from these
Discovery of (Aryloxopropenyl)pyrrolyl Hydroxyamides as Selective Inhibitors of Class IIa Histone Deacetylase Homologue HD1-A
Mai, Antonello,Massa, Silvio,Pezzi, Riccardo,Rotili, Dante,Loidl, Peter,Brosch, Gerald
, p. 4826 - 4829 (2007/10/03)
Chemical manipulations performed on aroyl pyrrolyl hydroxyamides, a new class of HDAC inhibitors previously reported by us, led to (aryloxopropenyl)pyrrolyl hydroxyamides 3a-g. Such compounds, showing better inhibitory activity against maize HD1-A than HD
