615286-59-4Relevant academic research and scientific papers
Cu(ii)-catalyzed highly regio- and stereoselective construction of C-C double bonds: An efficient method for the ketonization-olefination of indoles
Bao, Yun-Hong,Zhu, Jia-Yi,Qin, Wen-Bing,Kong, Yu-Bo,Chen, Zheng-Wang,Tang, Shao-Bin,Liu, Liang-Xian
supporting information, p. 7938 - 7945 (2013/11/19)
A general and efficient method for the cross-coupling of indoles with β-keto esters by using TEMPO/CuSO4·5H2O in air as oxidant has been developed. This reaction features high functional-group compatibility and an excellent selectivi
Synthesis and biological evaluation of pyridazino[4,3-b]indoles and indeno[1,2-c]pyridazines as new ligands of central and peripheral benzodiazepine receptors
Campagna, Francesco,Palluotto, Fausta,Mascia, Maria Paola,Maciocco, Elisabetta,Marra, Carla,Carotti, Angelo,Carrieri, Antonio
, p. 129 - 140 (2007/10/03)
A large number of pyridazino[4,3-b]indoles and indeno[1,2-c]pyridazines were synthesised and tested to evaluate their binding affinities at both central (CBR) and peripheral (PBR) benzodiazepine receptors. Relatively good PBR binding affinities were found for ligands belonging to the 3-arylmethyloxy-pyridazinoindole series, whereas only 2-aryl-indenopyridazines 7a, 8a and 10a display a weak binding affinity for CBR. To find out the main structural determinants affecting PBR affinity, a molecular modelling study based on the comparative analysis of the three-dimensional properties of four properly selected derivatives 24a, 3b, 18a and 10d, with those of highly active and selective PBR ligands, taken as reference, was performed.
