61532-43-2Relevant academic research and scientific papers
Peripherally acting anti-pruritic opiates
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, (2008/06/13)
Anti-pruritic compositions and methods of using the compositions for the prevention or treatment of pruritus comprising: wherein: R, R2, R3, R4, R7, Ar1and Ar2are as defined in the specification in a pharmaceutically acceptable carrier.
Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic conditions therewith
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, (2008/06/13)
Topical anti-hyperalgesic film-forming compositions and methods of using compositions for the treatment of peripheral hyperalgesia comprising: a) a compound of the formula STR1 wherein M is STR2 wherein: R, R2, R3, R4, R7, Ar1 and Ar2 are as defined in the specification; b) a film-forming polymeric material containing the hyperalgesic compound; and c) an aqueous pharmaceutically acceptable carrier.
1-(3,3,3-Triarylalkyl)-4-phenyl-piperidinealkanols
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, (2008/06/13)
The present invention encompasses compounds of the formula STR1 and pharmaceutically acceptable acid addition salts thereof wherein the Alk is straight or branched chain alkylene containing 2-4 carbon atoms; M is alkylene having 1-4 carbon atoms; Ar and Ar' are phenyl, alkyl substituted phenyl wherein the alkyl contains from 1-4 carbon atoms or halo substituted phenyl; Ar" is phenyl, alkyl substituted phenyl wherein the alkyl contains 1-4 carbon atoms, halo substituted phenyl or pyridyl; X is hydrogen, halogen, trifluoromethyl or alkyl having from 1-4 carbon atoms; R is hydrogen alkyl having from 1-7 carbon atoms or an alkanoyl having from 2-5 carbon atoms. These compounds are potent antidiarrheal agents characterized by little, if any, central nervous system activity.
