61535-24-8

Usage

General Description

2-amino-3-(benzyloxy)benzoic acid is a chemical compound that is commonly used in the development of pharmaceuticals and organic synthesis. It is an amino acid derivative with a benzyl ether group attached to the aromatic ring. 2-amino-3-(benzyloxy)benzoic acid has been identified as a potential drug candidate for the treatment of various diseases, including cancer and inflammation. Its structure and properties make it a valuable building block in the synthesis of complex molecules and a useful tool in medicinal chemistry research. 2-amino-3-(benzyloxy)benzoic acid is an important chemical with potential applications in the pharmaceutical industry and organic chemistry research.

Upstream product

• 24115-89-7 3-benzyloxy-2-nitrobenzoic acid 
• 4920-77-8 3-methyl-2-nitrophenol 
• 4920-80-3 3-methoxy-2-nitrobenzoic acid 
• 5345-42-6 1-methoxy-3-methyl-2-nitro-benzene 
• 1016556-84-5 2-azido-3-(benzyloxy)benzoic acid 
• 108-39-4 3-methyl-phenol 
• 602-00-6 3-hydroxy-2-nitrobenzoic acid 

Downstream Products

• 110575-89-8 (2-Amino-3-benzyloxy-phenyl)-((S)-2-dimethoxymethyl-pyrrolidin-1-yl)-methanone 
• 61535-25-9 3-Benzyloxy-2-iodo-benzoic acid 
• 61559-83-9 3-Benzyloxy-2-iodo-benzoyl chloride 
• 80279-24-9 tilivalline 
• 110562-23-7 O-benzyltilivalline 

Relevant academic research and scientific papers

Chemoselective aromatic azido reduction with concomitant aliphatic azide employing Al/Gd Triflates/Nal and ESI-MS mechanistic studies

Aluminium and gadolinium inflates catalyze the chemoselective reduction of aromatic azides to the corresponding amines in combination with sodium iodide. This mild chemoselective method has been applied to the synthesis of various aryl amines, C2azido-substituted pyrrolo[2,1-c]-[1,4]benzodiazepines, and fused[2,1b]quinazolinones by an intramolecular azido reduction tandem cyclization reaction. Interestingly, this methodology selectively reduces aryl azides with enhanced yields and proceeds in shorter reaction times than previous strategies. The mechanistic aspects have been investigated and the intermediates associated with this selective transformation have been intercepted and characterized by online monitoring of the reaction by ESI-MS.

One-pot microwave-assisted selective azido reduction/tandem cyclization in condensed and solid phase with nickel boride

An efficient and inexpensive method using microwave-assisted irradiation with Ni2B for the syntheses of aromatic amines, pyrrolobenzodiazepines as well as pyrroloquinazolinones was developed. This protocol was applied in the tandem resin-cleavage, azido reduction, and cyclization of compounds 3 and 5 that afforded substituted pyrrolo[2,1-c][1,4] benzodiazepines 4 and 6 in a one-pot manner. The microwave-assisted irradiation reactions enhanced yields with very short reaction times in contrast to the conventional thermal reactions. Georg Thieme Verlag Stuttgart.

Multisubstituted 1-hydroxy-9-acridones with anticancer activity

The present invention provides a compound having the structure: STR1 The present invention also provides a method for synthesizing a compound having the above-identified structure as well as the intermediate compounds produced according to that method. The present invention further provides a pharmaceutical composition comprising the above compounds. Lastly, the present invention provides a method of inhibiting growth of tumor cells.