61541-79-5

Basic information

• Product Name: 5-ETHYL-4-PHENYLPYRIMIDIN-2-AMINE
• Synonyms: 5-ETHYL-4-PHENYLPYRIMIDIN-2-AMINE;5-ethyl-4-phenyl-2-Pyrimidinamine
• CAS NO: 61541-79-5
• Molecular Formula: C₁₂H₁₃N₃
• Molecular Weight: 199.25172
• Mol File: 61541-79-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 68 °C(Solv: ethanol (64-17-5))
• Boiling Point: 423.8±53.0 °C(Predicted)
• Appearance: /
• Density: 1.130±0.06 g/cm3(Predicted)
• PKA: 4.11±0.10(Predicted)
• CAS DataBase Reference: 5-ETHYL-4-PHENYLPYRIMIDIN-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ETHYL-4-PHENYLPYRIMIDIN-2-AMINE(61541-79-5)
• EPA Substance Registry System: 5-ETHYL-4-PHENYLPYRIMIDIN-2-AMINE(61541-79-5)

Safety Data

• Hazardous Substances Data: 61541-79-5(Hazardous Substances Data)

Upstream product

• 506-93-4 guanidine nitrate 
• 495-40-9 propiophenone 
• 536-74-3 phenylacetylene 

Relevant articles and documents

A One-Pot Synthesis of 2-Aminopyrimidines from Ketones, Arylacetylenes, and Guanidine

The three-component reaction of ketones, arylacetylenes, and guanidine catalyzed by the KOBut/DMSO system leads to 2-aminopyrimidines in up to 80% yield. Depending on structure of the starting ketones, the aromatization of intermediate dihydropyrimidines occurs either with loss of hydrogen molecules or methylbenzenes. The latter process takes place in the ketones, in which one of the substituents is not a methyl group. The reaction conditions are tolerable for dialkyl-, aryl(hetaryl) alkyl-, and cycloalkyl ketones.