61548-76-3

Basic information

• Product Name: (S)-2-Phenylsuccinic acid dimethyl ester
• Synonyms: (S)-2-Phenylbutanedioic acid dimethyl ester;(S)-2-Phenylsuccinic acid dimethyl ester;[S,(+)]-Phenylsuccinic acid dimethyl ester;(S)-DIMETHYL 2-PHENYLSUCCINATE
• CAS NO: 61548-76-3
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.24
• Mol File: 61548-76-3.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-2-Phenylsuccinic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Phenylsuccinic acid dimethyl ester(61548-76-3)
• EPA Substance Registry System: (S)-2-Phenylsuccinic acid dimethyl ester(61548-76-3)

Safety Data

• Hazardous Substances Data: 61548-76-3(Hazardous Substances Data)

Usage

General Description

(S)-2-Phenylsuccinic acid dimethyl ester is a chemical compound that belongs to the class of succinic acid esters. It is a colorless, viscous liquid that is soluble in organic solvents. (S)-2-Phenylsuccinic acid dimethyl ester is commonly used as a building block in organic synthesis and as a reagent in chemical reactions. It has been studied for its potential applications in the pharmaceutical and agrochemical industries. The esterification of (S)-2-phenylsuccinic acid with methanol makes this compound useful in the production of flavors and fragrances. It is important to handle this chemical with caution due to its potential hazards such as skin and eye irritation, and it should be stored and disposed of properly in accordance with relevant regulations.

Upstream product

• 186581-53-3 diazomethane 
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• 67-56-1 methanol 
• 4036-30-0 (S)-2-phenylsuccinic acid 
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• 492-38-6 2-phenylacrylic acid 
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• 29576-99-6 dimethyl 2-(phenyl)maleate 
• 100-58-3 phenylmagnesium bromide 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 624-49-7 dimethylfumarate 
• 98-80-6 phenylboronic acid 
• 635-51-8 2-phenylsuccinic acid 
• 100-42-5 styrene 

Downstream Products

• 164653-83-2 methanesulfonic acid (S)-4-methanesulfonyloxy-3-phenyl-butyl ester 
• 883901-37-9 (S)-3-(4-nitro-phenyl)-1-propyl-pyrrolidine 
• 883901-38-0 (S)-3-(4-amino-phenyl)-1-propyl-pyrrolidine 
• 883901-36-8 (S)-3-phenyl-1-propyl-pyrrolidine 
• 61548-78-5 (S)-(1,4-dibromobutan-2-yl)benzene 
• 6837-05-4 (2S)-2-phenylbutane-1,4-diol 

Relevant articles and documents

Palladium-Catalyzed Asymmetric Hydroesterification of α-Aryl Acrylic Acids to Chiral Substituted Succinates

A palladium-catalyzed asymmetric hydroesterification of α-aryl acrylic acids with CO and alcohol was developed, preparing a variety of chiral α-substituted succinates in moderate yields with high ee values. The kinetic profile of the reaction progress revealed that the alkene substrate first underwent the hydroesterification followed by esterification with alcohol. The origin of the enantioselectivity was elucidated by density functional theory computation.

Autoinductive conversion of α,α-diiodonitroalkanes to amides and esters catalysed by iodine byproducts under O2

Studies to convert nitroalkanes into amides and esters using I2 and O2 revealed in situ-generated iodine species facilitate the homolytic C-I bond cleavage of α,α-diiodonitroalkanes, arguably in an autoinductive or autocatalytic manner. Consequently, we devised a rapid and economical I2/O2-based method to synthesise sterically hindered esters directly from primary nitroalkanes.

Nickel-catalyzed asymmetric transfer hydrogenation of conjugated olefins

Asymmetric transfer hydrogenation of electron-deficient olefins is realized with nickel catalysts supported by strongly σ-donating bisphosphines. Deuterium labeling experiments point to a reaction sequence of formate decarboxylation, asymmetric hydride in