61552-24-7

Upstream product

• 25245-34-5 1-bromo-2,5-dimethoxybenzene 
• 2150-40-5 methyl 2,5-dimethoxybenzoate 
• 61552-22-5 2,5-dimethoxyphenyl-[²H₂]methanol 
• 61552-23-6 (α,α-2H2)-2,5-dimethoxybenzyl bromide 

Downstream Products

• 609337-68-0 (α,α,α-2H3)-methylhydroquinone 
• 61552-26-9 C₁₂H₁₂⁽²⁾H₃NO₄ 
• 609337-69-1 (α,α,α-2H3)-4-benzoyloxy-2-methylphenol 
• 61552-25-8 2,5-Dimethoxy-4-trideuteriomethylbenzaldehyd 

Relevant academic research and scientific papers

Exhaustive Reduction of Esters Enabled by Nickel Catalysis

We report a one-step procedure to directly reduce unactivated aryl esters into their corresponding tolyl derivatives. This is achieved by an organosilane-mediated ester hydrosilylation reaction and subsequent Ni/NHC-catalyzed hydrogenolysis. The resulting conditions provide a direct and efficient alternative to multi-step procedures for this transformation that often require the use of hazardous metal hydrides. Applications in the synthesis of -CD3-containing products, derivatization of bioactive molecules, and chemoselective reduction in the presence of other C-O bonds are demonstrated.

First synthesis of (8-2H3)-(all-rac)-δ-tocopherol

Trideuterated tocopherols were needed to be used as internal standards for our study about simultaneous quantitative determination of tocopherols in foodstuffs by mass spectrometry. Whilst procedures for trideuterated α-tocopherol have been recently optimized, no method is reported as regards δ-tocopherol. Different synthetic approaches are discussed, as well as the first procedure for the synthesis of (8-2H3)-(all-rac)-δ-tocopherol. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.