615535-60-9Relevant academic research and scientific papers
Synthesis and structure-activity relationship of imidazo(1,2-a)thieno(3,2-e)pyrazines as IKK-β inhibitors
Belema, Makonen,Bunker, Amy,Nguyen, Van N.,Beaulieu, Francis,Ouellet, Carl,Qiu, Yuping,Zhang, Yunhui,Martel, Alain,Burke, James R.,McIntyre, Kim W.,Pattoli, Mark A.,Daloisio, Connie,Gillooly, Kathleen M.,Clarke, Wendy J.,Brassil, Patrick J.,Zusi, F. Chris,Vyas, Dolatrai M.
, p. 4284 - 4289 (2008/02/10)
The identification of a potent series of IKK-β selective inhibitors based on an imidazothienopyrazine template and the oral efficacy of one such analog (22j) in the LPS-induced TNF-α release mouse model are described.
