615551-76-3Relevant academic research and scientific papers
SYNZHESIS OF (7E,9E,11E,13E)-18,18,18-TRIFLUORORETINAL (ALL-TRANS 5-TRIFLUOROMETHYLRETINAL)
Taguchi, Takeo,Hodosa, Akihiko,Kobayashi, Yoshiro
, p. 6209 - 6212 (1985)
All-trans-18,18,18-trifluororetinal (2) was synthesized through trifluorocyclocitral (3) as a key intermediate.
Total synthesis of a novel 2-thiabicyclo[3.2.0]heptan-6-one analogue of penicillin N
Ferguson, Amanda C.,Adlington, Robert M.,Martyres, Domnic H.,Rutledge, Peter J.,Cowley, Andrew,Baldwin, Jack E.
, p. 8233 - 8243 (2007/10/03)
A route has been developed which allows synthesis of novel cyclobutanone analogues of penicillin. This is illustrated by the synthesis of (1R,4R,5R,5′R,7S)-(1b) and (1S,4S,5S,5′R,7R)-7-[5′ -amino-5′-carboxy]pentanamido]-2-thiabicyclo[3.2.0] heptan-6-one-4-carboxylate (1a), an analogue of penicillin N. The key steps in the synthesis were the formation of the bicyclic structure via a [2+2] cycloaddition and the introduction of nitrogen at C7 via an intramolecular nitrene insertion.
