615575-74-1

Usage

Uses

Used in Pharmaceutical Industry:
RaceMic 2-aza-bicyclo[2.1.1]hexane-2,5-dicarboxylic acid 2-tert-butyl ester is used as a building block in organic synthesis for the development of new drug candidates. Its unique structure and properties make it a valuable component in the synthesis of various pharmacologically active compounds, contributing to the advancement of drug discovery and innovation.
Used in Organic Synthesis:
RaceMic 2-aza-bicyclo[2.1.1]hexane-2,5-dicarboxylic acid 2-tert-butyl ester is used as a starting material in organic synthesis, allowing chemists to create a wide range of chemical compounds with diverse applications. Its versatility and reactivity make it an essential component in the synthesis of various organic compounds, further expanding its utility in the field of chemistry.

Upstream product

• 1256914-47-2 5-carboxylic-N-Boc-2-azabicyclo[2.1.1]-hexane α-methylbenzylamine 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 359779-73-0 5-acetyl-2-aza-bicyclo[2.1.1]hexane-2-carboxylic acid tert-butyl ester 
• 92676-73-8 trans-1-allylamino-1-buten-3-one 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant academic research and scientific papers

Transfer of photochemistry from UV to visible: An expedient access to a bridged pyrrolidine

In this study we successfully transferred a useful photochemical reaction from the UV to the visible region of the spectrum. Use of a commercially available iridium complex facilitated triplet state intramolecular [2 + 2] photocycloaddition under irradiation with the now readily available, compact and convenient blue light sources, therefore avoiding the need for direct UV irradiation. Under these mild conditions, we enabled the efficient production of gram quantities of a medicinally relevant yet underexploited bridged pyrrolidine in a standard research lab fumehood.

Oligomers of a 5-carboxy-methanopyrrolidine β-amino acid. A search for order

CD spectra for homooligomers (n = 4, 6, 8) of (1S,4R,5R)-5-syn-carboxy-2- azabicyclo[2.1.1]hexane (MPCA), a methano-bridged pyrrolidine β-carboxylic acid, suggest an ordered secondary structure. Even in the absence of internal hydrogen bonding, solution N

5-Carboxy-2-azabicyclo[2.1.1]hexanes as precursors of 5-halo, amino, phenyl, and 2-methoxycarbonylethyl methanopyrrolidines

Novel 5-X-substituted-2-azabicyclo[2.1.1]hexanes (X = 5-syn-Cl, -Br, -I, -Ph, -NHCOOR (R = Me, Bn, t-Bu), -CH2CH2COOMe and X = 5-anti-Br, -I, -Ph) were synthesized from the X = 5-syn-carboxy derivative. New 5-anti-X-2-azabicyclo[2.1.

Convenient preparations of 2,4-methanopyrrolidine and 5-carboxy-2,4-methanopyrrolidines

An efficient four-step synthesis of N-BOC-5-syn- and 5-anti-carboxymethanopyrrolidines (12 and 13) and the conversion of 12 to N-BOC-methanopyrrolidine (2) are described.