615578-60-4Relevant academic research and scientific papers
Synthesis and evaluation of a 2-benzothiazolylphenylmethyl ether class of histamine H4 receptor antagonists
Labeeuw, Olivier,Levoin, Nicolas,Billot, Xavier,Danvy, Denis,Calmels, Thierry,Krief, Stéphane,Ligneau, Xavier,Berrebi-Bertrand, Isabelle,Robert, Philippe,Lecomte, Jeanne-Marie,Schwartz, Jean-Charles,Capet, Marc
, p. 5263 - 5266 (2016/10/30)
Synthesis and biological evaluation of a new class of histamine H4receptor ligands, distinct from the previously reported chemotypes, are described. A virtual screening of our corporate compound collection identified a hit with an undesired dual H3R/H4R activity. Chemical exploration led to the discovery of a more potent and selective 2-benzothiazolylphenylmethyl ether lead compound.
NOVEL COMPOUNDS
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Page/Page column 25, (2010/02/07)
Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis. In Formula (I) R1, R2, R3, R4, R5, R6, X and Y are as d
