615581-61-8

Basic information

• Product Name: methyl 4-methyl-3-(4-oxopentyl)benzoate
• Synonyms: methyl 4-methyl-3-(4-oxopentyl)benzoate
• CAS NO: 615581-61-8
• Molecular Weight: 234.295
• Mol File: 615581-61-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 4-methyl-3-(4-oxopentyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-methyl-3-(4-oxopentyl)benzoate(615581-61-8)
• EPA Substance Registry System: methyl 4-methyl-3-(4-oxopentyl)benzoate(615581-61-8)

Safety Data

• Hazardous Substances Data: 615581-61-8(Hazardous Substances Data)

Upstream product

• 111957-98-3 Pent-4-en-2-ol 
• 615582-35-9 methyl 3-(4-hydroxypentyl)-4-methylbenzoate 
• 104901-43-1 methyl 3-bromo-4-methylbenzoate 

Relevant articles and documents

Samarium(II)-promoted radical spirocyclization onto an aromatic ring

Samarium(II)-mediated spirocyclization onto an aromatic ring was achieved by the reaction of methyl 4-(4-oxoalkyl)benzoates with SmI2 in the presence of i-PrOH and HMPA, yielding methyl 1-alkyl-1-hydroxyspiro[4.5]dec-6-ene-8-carboxylates in moderate to high yields. Utilizing this chemistry, spiro[3.5] and -[5.5] systems, and sterically congested spiro[4.5] systems, were easily synthesized. For the successful conversion, appropriate activation of the aromatic ring has proven to be extremely important: while an ester or amide functionality on the aromatic ring can promote the spirocyclization, a sulfonamide substituent causes ortho cyclization.