61561-22-6

Upstream product

• 83585-22-2 methyl 2-(3-methoxyphenyl)-2-oxoacetate 
• 1254217-27-0 ethyl (3-tert-butyldimethylsilyloxyphenyl)(oxo)acetate 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 26767-10-2 2-(3-methoxyphenyl)glyoxylic acid 

Downstream Products

• 66340-53-2 methyl 2-methoxyimino-2-(3-hydroxyphenyl)acetate 
• 66340-52-1 (3-Hydroxy-phenyl)-[(Z)-methoxyimino]-acetic acid methyl ester 
• 61561-23-7 2-hydroxyimino-2-(3-hydroxyphenyl)acetic acid 
• 53623-77-1 m-hydroxymandelic acid 
• 66340-84-9 (3-Carbamoyloxy-phenyl)-[(Z)-methoxyimino]-acetic acid 
• 66340-67-8 2-methoxyimino-2-(3-methoxyphenyl)acetic acid 
• 66340-66-7 [(Z)-Methoxyimino]-(3-methoxy-phenyl)-acetic acid 
• 66340-65-6 methyl 2-methoxyimino-2-(3-methoxyphenyl)acetate 
• 66340-64-5 (Z)-methyl 2-(methoxyimino)-2-(3-methoxyphenyl)acetate 
• 66340-61-2 2-allyloxyimino-2-(3-hydroxyphenyl)acetic acid 
• 66340-82-7 (3-Acetoxy-phenyl)-[(Z)-methoxyimino]-acetic acid 
• 61561-01-1 C₈H₇NO₄ 
• 66340-74-7 [(Z)-Ethoxyimino]-(3-hydroxy-phenyl)-acetic acid 
• 66340-78-1 (3-Hydroxy-phenyl)-[(Z)-phenylsulfanylmethoxyimino]-acetic acid 

Relevant academic research and scientific papers

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor

Aromatic analogues of the 2-oxoglutarate co-substrate of the hypoxia-inducible factor hydroxylases are shown to bind at the active site iron: Pyridine-2,4-dicarboxylate binds as anticipated with a single molecule chelating the iron in a bidentate manner. The binding mode of a hydroxamic acid analogue, at least in the crystalline state, is unusual because two molecules of the inhibitor are observed at the active site and partial displacement of the iron binding aspartyl residue was observed.