61563-33-5 Usage
Uses
Used in Organic Chemistry:
8-Chloro-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride is used as a substrate for the synthesis of more complex organic compounds. Its unique structure allows for the creation of a variety of chemical entities, making it a valuable component in the field of organic chemistry.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 8-Chloro-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride is used as a starting material for the development of new drugs. Its potential reactivity and stability contribute to the exploration of its properties and possible applications in medicinal chemistry.
Used in Research and Development:
8-Chloro-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride is employed as a research compound in various scientific fields. Its specific properties make it highly valuable for experiments and the synthesis of other chemicals, contributing to the advancement of knowledge in chemistry and related disciplines.
Check Digit Verification of cas no
The CAS Registry Mumber 61563-33-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,5,6 and 3 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 61563-33:
(7*6)+(6*1)+(5*5)+(4*6)+(3*3)+(2*3)+(1*3)=115
115 % 10 = 5
So 61563-33-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H10ClN.ClH/c10-9-3-1-2-7-4-5-11-6-8(7)9;/h1-3,11H,4-6H2;1H
61563-33-5Relevant academic research and scientific papers
Synthesis and further transformations of 8-chloro-3,4-dihydroisoquinoline
Hargitai, Csilla,Nagy, Tamás,Halász, Judit,Koványi-Lax, Gy?rgyi,Németh, Gábor,Simig, Gyula,Volk, Balázs
, p. 7009 - 7017 (2018/10/24)
Two procedures for the synthesis of barely accessible 8-chloro-3,4-dihydroisoquinoline were investigated. The first approach is based on a directed ortho-lithiation of N-pivaloyl meta-chlorophenylethylamine, followed by formylation and subsequent ring closure under acidic conditions. In the second, more advantageous variant, the N-hydroxyethyl ortho-chlorobenzylamine intermediate undergoes a Friedel-Crafts reaction, and the resulting tetrahydro derivative is oxidized with N-bromosuccinimide. The 8-chloro-3,4-dihydroisoquinoline key intermediate is then applied in Suzuki reactions to give various 8-aryl-3,4-dihydroisoquinolines, which are finally treated with alkyl or aryllithiums to give 1-substituted 8-aryl-1,2,3,4-tetrahydroisoquinolines. These novel 1,2,3,4-tetrahydroisoquinoline derivatives can be used as building blocks in the synthesis of potential drug candidates.
Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase
-
, (2008/06/13)
Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using 7 and/or 8 substituted 1,2,3,4-tetrahydroisoquinoline compounds.
