61585-29-3

Basic information

• Product Name: Impurity A of Calcifediol
• CAS NO: 61585-29-3
• Molecular Weight: 400.645
• Mol File: 61585-29-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Impurity A of Calcifediol(CAS DataBase Reference)
• NIST Chemistry Reference: Impurity A of Calcifediol(61585-29-3)
• EPA Substance Registry System: Impurity A of Calcifediol(61585-29-3)

Safety Data

• Hazardous Substances Data: 61585-29-3(Hazardous Substances Data)

Usage

General Description

Impurity A of Calcifediol is a chemical compound that is considered a potential impurity in the pharmaceutical substance calcifediol. It is classified as an organic compound and is specifically identified as 24,25-dihydroxyvitamin D3. This impurity may be present in small amounts in calcifediol preparations and is subject to regulation and monitoring in pharmaceutical manufacturing processes. Impurity A of Calcifediol is a key focus in ensuring the purity and quality of calcifediol products for medical and therapeutic use. Regulatory authorities, such as the United States Pharmacopeia (USP) and the European Pharmacopoeia, have established guidelines and specifications for the allowable levels of impurities in pharmaceutical substances including calcifediol.

Upstream product

• 2140-46-7 25-hydroxychlolesterol 

Downstream Products

• 1715-86-2 cholesta-5,7,24-triene-3β-ol 
• 23357-18-8 25-hydroxy previtamin D₃ 
• 19356-17-3 calcidiol 

Relevant articles and documents

NOVEL METHOD FOR SYNTHESIZING 25-OH CHOLESTEROL/CALCIFEDIOL FROM PHYTOSTEROL

The present invention discloses novel method for synthesizing vegan 25-OH cholesterol/Calcifediol from inexpensive crude phytosterol. According to the method, Phytosterols are reacted to form corresponding i-steroid through tosylation and methanolysis. i-steroid on reductive ozonolysis to C-22 alcohol and conversion via C-22 tosylate to C-22 iodide in good yield. Coupling of C-22 tosylate with Grignard reagent of 4-bromo-2-methyl-2-[(trimethylsilyl)oxy] butane followed by deprotection yielded 25-OH cholesterol. In a process variant, nickel mediated conjugate addition of C-22 iodide to an electron deficient alkene ethyl acrylate and treating corresponding ester with methyl magnesium bromide as means of installing the side chain of 25-OH cholesterol in high yield. Further bromination reaction of 25-OH cholesterol diacetate followed by dehydrobromination using TBAF yielded 25-OH 7-dehydrocholesterol. Further photo reaction of 25-OH 7-dehydrocholesterol in to previtamin D3 using high or medium pressure mercury lamp and subsequent thermal reaction of previtamin D3 to 25-OH vitamin D3(Calcifediol) in good yield.