61609-23-2Relevant academic research and scientific papers
Microwave-Enhanced Coupling of Carboxylic Acids with Liquid Ketones and Cyclic Ethers Using Tetrabutylammonium Iodide/ t-Butyl Hydroperoxide
Macías-Benítez, Pablo,Moreno-Dorado, F. Javier,Guerra, Francisco M.
, p. 6027 - 6043 (2020/05/22)
The oxidative coupling of carboxylic acids with liquid ketones and cyclic ethers has been accomplished in minutes using t-butyl hydroperoxide in the presence of tetrabutylammonium iodide under microwave irradiation in the absence of a solvent. In addition to drastically shortening the reaction times, the use of microwaves resulted, in general, in yields equal to or higher than those obtained by conventional heating.
C–O bond formation via oxidative-coupling pathway in eutectic mixture of choline chloride/urea as a green solvent
Saberi, Dariush,Manouchehri, Neda,Niknam, Khodabakhsh
, p. 680 - 687 (2019/01/03)
C–O bond formation between terminal alkenes/benzyl alcohols as an arylcarboxy surrogate and carbonyl compounds in a biodegradable deep eutectic solvent (DES) based on choline chloride and urea was performed. By employment of TBAI as catalyst and TBHP as oxidant, various derivatives of carbonyl compounds were benzylated in α position in good to high yield at 90 °C. Moreover, α-oxybenzoylation of diethyl malonate with carboxylic acids was performed in the above-mentioned DES by employment of NaI as the catalyst and TBHP as the oxidant at 60 °C.
The Bu4NI-catalyzed alfa-acyloxylation of ketones with benzylic alcohols
Guo, Songjin,Yu, Jin-Tao,Dai, Qiang,Yang, Haitao,Cheng, Jiang
supporting information, p. 6240 - 6242 (2014/06/09)
The Bu4NI-catalyzed reaction of ketones with benzylic alcohols was achieved, leading to alfa-acyloxycarbonyl compounds in moderate to good yields. This metal-free procedure featured the employment of facilely and commercially available starting materials and TBHP as a clean oxidant with high atom economy. This journal is the Partner Organisations 2014.
Asymmetric α-oxyacylation of cyclic ketones
Smithen, Deborah A.,Mathews, Christopher J.,Tomkinson, Nicholas C.O.
, p. 3756 - 3762 (2012/06/01)
Reaction of cyclic ketones with chiral N-alkyl-O-acyl hydroxylamines leads to the corresponding α-oxyacylated carbonyl compound in up to 89% ee. The levels of asymmetric induction were influenced by solvent polarity, acid strength and, to a lesser extent,
A general method for the α-acyloxylation of carbonyl compounds
Beshara, Cory S.,Hall, Adrian,Jenkins, Robert L.,Jones, Kerri L.,Jones, Teyrnon C.,Killeen, Niall M.,Taylor, Paul H.,Thomas, Stephen P.,Tomkinson, Nicholas C. O.
, p. 5729 - 5732 (2007/10/03)
(Chemical Equation Presented) A simple, one-pot method for the α-acyloxylation of carbonyl compounds that proceeds at room temperature in the presence of both moisture and air has been developed. Treatment of a variety of aldehydes and both cyclic and acy
