6161-83-7

Basic information

• Product Name: 2-(3-CHLOROPHENOXY)ETHANOL
• Synonyms: Einecs 228-191-8;2-(3-CHLOROPHENOXY)ETHANOL
• CAS NO: 6161-83-7
• Molecular Formula: C₈H₉ClO₂
• Molecular Weight: 172.61
• EINECS: 228-191-8
• Mol File: 6161-83-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 279.7 °C at 760 mmHg
• Flash Point: 123 °C
• Appearance: /
• Density: 1.238 g/cm³
• Vapor Pressure: 0.00188mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: 2-(3-CHLOROPHENOXY)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-CHLOROPHENOXY)ETHANOL(6161-83-7)
• EPA Substance Registry System: 2-(3-CHLOROPHENOXY)ETHANOL(6161-83-7)

Safety Data

• Hazardous Substances Data: 6161-83-7(Hazardous Substances Data)

Usage

General Description

2-(3-chlorophenoxy)ethanol, also known as 3-chlorophenoxyethanol or ethylene chlorohydrin, is a chemical compound with the molecular formula C8H9ClO2. It is a colorless liquid with a slightly sweet odor and is commonly used as a solvent in various industrial processes. It is also used as a precursor in the synthesis of other chemicals such as pharmaceuticals, pesticides, and dyes. However, it is important to handle this compound with caution as it is considered to be toxic and may cause irritation to the skin, eyes, and respiratory system upon exposure. Additionally, it is recognized as a potential environmental hazard and may pose risks to aquatic organisms and wildlife.

InChI:InChI=1/C8H9ClO2/c9-7-2-1-3-8(6-7)11-5-4-10/h1-3,6,10H,4-5H2

Upstream product

• 108-37-2 1-bromo-3-chlorobenzene 
• 107-21-1 ethylene glycol 
• 108-43-0 3-monochlorophenol 
• 107-07-3 2-chloro-ethanol 
• 108-46-3 recorcinol 
• 49650-88-6 O-(2-hydroxyethyl)resorcinol 
• 3046-27-3 sodium m-chlorophenoxide 
• 588-32-9 3-chlorophenoxyacetic acid 
• 75-21-8 oxirane 

Downstream Products

• 108-43-0 3-monochlorophenol 
• 1611492-83-1 C₁₁H₁₃ClO₃ 
• 1579960-87-4 1-(4-(2-(tert-butyl)phenyl)piperazin-1-yl)-3-(2-(3-chlorophenoxy)ethoxy)propan-2-ol 
• 34272-74-7 2-(3-chlorophenoxy)ethyl chloride 
• 112442-19-0 1-[2-(3-chloro-phenoxy)-ethyl]-4-phenyl-piperidine-4-carboxylic acid ethyl ester 
• 25781-99-1 3-(2-hydroxyethoxy)benzoic acid 

Relevant articles and documents

Copper(ii)-catalyzed C-O coupling of aryl bromides with aliphatic diols: Synthesis of ethers, phenols, and benzo-fused cyclic ethers

A highly efficient copper-catalyzed C-O cross-coupling reaction between aryl bromides and aliphatic diols has been developed employing a cheaper, more efficient, and easily removable copper(ii) catalyst. A broad range of aryl bromides were coupled with aliphatic diols of different lengths using 5 mol% CuCl2 and 3 equivalents of K2CO3 in the absence of any other ligands or solvents to afford the corresponding hydroxyalkyl aryl ethers in good to excellent yields. In this newly developed protocol, aliphatic diols have multilateral functions as coupling reactants, ligands, and solvents. The resulting hydroxyalkyl aryl ethers were further readily converted into the corresponding phenols, presenting a valuable alternative way to phenols from aryl bromides. Furthermore, it was demonstrated that they are useful intermediates for more advanced molecules such as benzofurans and benzo-fused cyclic ethers. This journal is

SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF

Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.

Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals

Methods of treating chronic arthritis and osteoporosis which utilize both known and novel compounds which would fall under the general formula:(HO)p--A--[--OS(O) 2 NR 1 R 2 ] zwherein A encompasses a wide range of values including but not limited to aryl, loweralkyl, cycloalkyl, and carbohydrates including sucrose and fructose; p is equal to the number of unreacted hydroxy groups contained on the molecule and may be zero; z is the number of --OS(O) 2 NR 1 R 2 groups and is always at least one; R 1 and R 2 are selected from hydrogen, loweralkyl, carboxy and the like; a novel process for preparing the compounds is provided wherein an appropriate sulfamic acid aryl ester is reacted with a hydroxy substituted A radical which may or may not contain thereon protected carboxyl, amino or hydroxy substituents, in an aprotic solvent containing a tertiary amine base. Pharmaceutical compositions for the treatment of chronic arthritis and osteoporosis are also provided.