6161-83-7

Usage

Uses

Used in Chemical Synthesis:
2-(3-CHLOROPHENOXY)ETHANOL is used as a precursor in the chemical synthesis industry for the production of various compounds, including pharmaceuticals, pesticides, and dyes. Its reactivity and versatility make it a valuable intermediate in the creation of a wide range of products.
Used in Industrial Processes:
In the industrial sector, 2-(3-CHLOROPHENOXY)ETHANOL is utilized as a solvent for various processes. Its solvent properties are leveraged to dissolve and process other substances in manufacturing operations, contributing to the efficiency and effectiveness of these processes.
Used in Environmental Management:
While 2-(3-CHLOROPHENOXY)ETHANOL is recognized as a potential environmental hazard, its management and use are critical in minimizing its impact on aquatic organisms and wildlife. Efforts in environmental management aim to regulate its use and disposal to prevent contamination and protect ecosystems.

InChI:InChI=1/C8H9ClO2/c9-7-2-1-3-8(6-7)11-5-4-10/h1-3,6,10H,4-5H2

Upstream product

• 75-21-8 oxirane 
• 108-43-0 3-monochlorophenol 
• 107-07-3 2-chloro-ethanol 
• 108-37-2 1-bromo-3-chlorobenzene 
• 107-21-1 ethylene glycol 
• 108-46-3 recorcinol 
• 49650-88-6 O-(2-hydroxyethyl)resorcinol 
• 3046-27-3 sodium m-chlorophenoxide 
• 588-32-9 3-chlorophenoxyacetic acid 

Downstream Products

• 34272-74-7 2-(3-chlorophenoxy)ethyl chloride 
• 108-43-0 3-monochlorophenol 
• 1611492-83-1 C₁₁H₁₃ClO₃ 
• 1579960-87-4 1-(4-(2-(tert-butyl)phenyl)piperazin-1-yl)-3-(2-(3-chlorophenoxy)ethoxy)propan-2-ol 
• 25781-99-1 3-(2-hydroxyethoxy)benzoic acid 
• 112442-19-0 1-[2-(3-chloro-phenoxy)-ethyl]-4-phenyl-piperidine-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold

Previously, we identified 1-(2-(4-bromophenoxy)ethoxy)-3-(4-(2- methoxyphenyl)piperazin-1-yl)propan-2-ol (1) as a novel Hsp90 inhibitor with moderate activity through virtual screening. In this study, we report the optimization process of 1. A series of analogues containing the 1-phenylpiperazine core scaffold were synthesized and evaluated. The structure-activity relationships (SAR) for these compounds was also discussed for further molecular design. This effort afforded the most active inhibitor 13f with improved activity in not only target-based level, but also cell-based level compared with the original hit 1.

Copper(ii)-catalyzed C-O coupling of aryl bromides with aliphatic diols: Synthesis of ethers, phenols, and benzo-fused cyclic ethers

A highly efficient copper-catalyzed C-O cross-coupling reaction between aryl bromides and aliphatic diols has been developed employing a cheaper, more efficient, and easily removable copper(ii) catalyst. A broad range of aryl bromides were coupled with aliphatic diols of different lengths using 5 mol% CuCl2 and 3 equivalents of K2CO3 in the absence of any other ligands or solvents to afford the corresponding hydroxyalkyl aryl ethers in good to excellent yields. In this newly developed protocol, aliphatic diols have multilateral functions as coupling reactants, ligands, and solvents. The resulting hydroxyalkyl aryl ethers were further readily converted into the corresponding phenols, presenting a valuable alternative way to phenols from aryl bromides. Furthermore, it was demonstrated that they are useful intermediates for more advanced molecules such as benzofurans and benzo-fused cyclic ethers. This journal is

SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF

Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.

Sulfamates as antiglaucoma agents

Sulfamate esters of the formula where A is aryloxyalkyl, p is the number of unreacted hydroxy groups present on the alkyl moiety and may be zero, z is the number of --OS(O)2 NR1 R2 groups attached to carbons of the alkyl moiety and is always at least one; R1 and R2 are selected from hydrogen, loweralkyl, carboxy, and the like are useful in treating glaucoma.

Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals

Methods of treating chronic arthritis and osteoporosis which utilize both known and novel compounds which would fall under the general formula:(HO)p--A--[--OS(O) 2 NR 1 R 2 ] zwherein A encompasses a wide range of values including but not limited to aryl, loweralkyl, cycloalkyl, and carbohydrates including sucrose and fructose; p is equal to the number of unreacted hydroxy groups contained on the molecule and may be zero; z is the number of --OS(O) 2 NR 1 R 2 groups and is always at least one; R 1 and R 2 are selected from hydrogen, loweralkyl, carboxy and the like; a novel process for preparing the compounds is provided wherein an appropriate sulfamic acid aryl ester is reacted with a hydroxy substituted A radical which may or may not contain thereon protected carboxyl, amino or hydroxy substituents, in an aprotic solvent containing a tertiary amine base. Pharmaceutical compositions for the treatment of chronic arthritis and osteoporosis are also provided.