616215-38-4

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 78136-16-0 2,3,4,6-tetra-O-benzyl-D-glucitol 
• 616215-36-2 (3R,4R,5S)-1,3,4,5-tetrakis(benzyloxy)-6-(tert-butyldiphenylsilyloxy)hexan-2-ol 
• 4291-69-4 2,3,4,6-Tetra-O-benzyl-D-glucopyranose 

Downstream Products

• 1335016-29-9 ethyl (3R,4S,5S,6R,7R)-7-azido-4,5,6,8-tetrakis(benzyloxy)-3-hydroxyoctanoate 
• 617688-50-3 5-azido-2,3,4,6-tetra-O-benzyl-5-deoxy-L-iditol 
• 616215-39-5 5-azido-2,3,4,6-tetra-O-benzyl-5-deoxy-L-idose 
• 1426550-39-1 pentyl 3,4,5,7-tetra-O-benzyl-2,6-dideoxy-2,6-imino-L-glycero-D-idoheptonamide 
• 1426550-38-0 pentyl 3,4,5,7-tetra-O-benzyl-2,6-dideoxy-2,6-imino-L-glycero-D-guloheptonamide 
• 1426550-37-9 1,1,3,3-tetramethylbutyl 3,4,5,7-tetra-O-benzyl-2,6-dideoxy-2,6-imino-L-glycero-D-idoheptonamide 
• 1426550-36-8 1,1,3,3-tetramethylbutyl 3,4,5,7-tetra-O-benzyl-2,6-dideoxy-2,6-imino-L-glycero-D-guloheptonamide 
• 1426550-35-7 5-(adamantan-1-yl-methoxy)pentyl 3,4,5,7-tetra-O-benzyl-2,6-dideoxy-2,6-imino-L-glycero-D-idoheptonamide 
• 1426550-34-6 5-(adamantan-1-yl-methoxy)pentyl 3,4,5,7-tetra-O-benzyl-2,6-dideoxy-2,6-imino-L-glycero-D-guloheptonamide 
• 1426550-33-5 pentyl 3,4,5,7-tetra-O-benzyl-2,6-dideoxy-2,6-(pent-4-enimido)-L-glycero-D-idoheptonamide 
• 1426550-32-4 pentyl 3,4,5,7-tetra-O-benzyl-2,6-dideoxy-2,6-(pent-4-enimido)-L-glycero-D-guloheptonamide 
• 1426550-31-3 1,1,3,3-tetramethylbutyl 3,4,5,7-tetra-O-benzyl-2,6-dideoxy-2,6-(pent-4-en-imido)-L-glycero-D-idoheptonamide 
• 1426550-30-2 1,1,3,3-tetramethylbutyl 3,4,5,7-tetra-O-benzyl-2,6-dideoxy-2,6-(pent-4-en-imido)-L-glycero-D-guloheptonamide 
• 1426550-29-9 5-(adamantan-1-yl-methoxy)pentyl 3,4,5,7-tetra-O-benzyl-2,6-dideoxy-2,6-(pent-4-enimido)-L-glycero-D-idoheptonamide 

Relevant academic research and scientific papers

The development of an aza-C-glycoside library based on a tandem staudinger/aza-wittig/ugi three-component reaction

We report the tandem Staudinger/aza-Wittig/Ugi three-component reaction mediated synthesis of a 64-member compound library of aza-C-glycosides. The library is composed of four pyrrolidine and three piperidine scaffolds, onto which a number of functional groups is grafted to form seven sublibraries. Variation in the library is achieved by transformation of two pentoses and a hexose into the corresponding 4-azidopentanal and 5-azidohexanal derivatives as precursors for the Staudinger/aza-Wittig process. Further variation is achieved by using different isocyanides as well as protective- and functional-group manipulations on the fully protected Ugi-3CR intermediates. Preliminary biological evaluation of the compound library revealed several low micromolar inhibitors of human acid glucosylceramidase.

Iminosugar analogues of phosphatidyl inositol as potential inhibitors of protein kinase B (Akt)

A small virtual library of iminosugar derivatives was evaluated by docking experiments carried out by sampling a protein region corresponding to the phosphoinositide binding site of the PH domain of Akt. Four compounds were selected and efficiently synthesised from a common precursor. All compounds were subjected to preliminary biological evaluation on purified enzyme, and - among them - compound 9 exhibited the best inhibitory activity. A small virtual library of iminosugar-based Akt inhibitors have been designed and evaluated by using docking calculations. Selected compounds have been conveniently synthesised, and preliminary biological evaluation identified compound 9 as a possible lead compound for further development of iminosugar-based Akt inhibitors. Copyright