616240-06-3Relevant academic research and scientific papers
Alkynyltrifluoroborates as versatile tools in organic synthesis: A new route to spiroketals
Doubsky, Jan,Streinz, Ludvik,Saman, David,Zednik, Jiri,Koutek, Bohumir
, p. 4909 - 4911 (2007/10/03)
(Chemical Equation Presented) A simple and efficient two-step approach to spiroketals is described. Key steps include the preparation of functionalized hydroxyl α-alkynones by ring-opening reactions of lactones with lithium alkynyltrifluoroborates followed by a palladium-catalyzed hydrogenation/ spirocyclization of the prespiroketal intermediate.
Ring-opening of lactones with alkynyltrifluoroborates: A new route to functionalized α-alkynones
Doubsky, Jan,Streinz, Ludvík,Le?eticky, Ladislav,Koutek, Bohumír
, p. 937 - 942 (2007/10/03)
Alkynyltrifluoroborate salts, readily generated in situ by the addition of BF3·OEt2 to alkynyllithiums, were shown to mediate the regioselective acyl C-O ring cleavage of 5-, 6-, and 7-membered lactones. This novel, operationally sim
